金山科研平台，产品价格货期咨询微信：jinshanbio Source:E. coli-derived, His26-Gln177, with an N-terminal Met Accession #:Q29056 N-terminal Sequence Analysis:Met Purity:>97%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:17 kDa Activity:Measured by its ability to inhibit IL-1 alpha -dependent proliferation in D10.G4.1 mouse helper T cells. Symons, J.A. etal. (1987) in Lymphokines and Interferons, a Practical Approach. Clemens, M.J. etal. (eds): IRL Press. 272.The ED₅₀ for this effect is typically 0.02-0.06µg/mL in the presence of 75 pg/mL of rpIL-1 alpha. Molecule Information: IL-1ra/IL-1F3 Long Name: Interleukin 1 Receptor Antagonist Aliases: IL-1F3; IL1RN Entrez Gene IDs: 3557 (Human); 16181 (Mouse); 60582 (Rat); 397499 (Porcine) Background: IL-1ra/IL-1F3 IL-1 receptor antagonist (IL-1ra) was originally isolated from the urine of patients with monocytic leukemia and has also been purified from adherent monocytes. The protein shows 26% amino acid homology to IL-1 beta and 19% homology to IL-1 alpha. It will compete with either factor for receptor binding, but does not interact with either one. Human IL-1ra will bind to both types of IL-1 receptor (I and II) on human cells. In mouse, IL-1RII does not bind IL-1ra.