金山科研平台，产品价格货期咨询微信：jinshanbio Source:Chinese Hamster Ovary cell line, CHO-derived Accession #:NP_002333 N-terminal Sequence Analysis:Ser28 Structure:Disulfide-linked homodimer Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:48.5 kDa (monomer) SDS-PAGE:60-66 kDa, reducing conditions Activity:Measured by its ability to inhibit Lymphotoxin alpha 1/beta 2-induced IL-8 secretion in A375 human melanoma cells. Degli-Esposti, M. et al. (1997) J. Immunol. 158:1756.The ED₅₀ for this effect is typically 2-10 ng/mL in the presence of 10 ng/mL of Recombinant Human Lymphotoxin alpha 1/beta 2 (Catalog# 678-LY). Formulation:Lyophilized from a 0.2 µm filtered solution in PBS.See Certificate of Analysis for details. Molecule Information: Lymphotoxin beta R/TNFRSF3 Long Name: Lymphotoxin beta Receptor Aliases: LTBR; TNF RIII; TNF Rrp; TNFRSF3 Entrez Gene IDs: 4055 (Human); 17000 (Mouse); 297604 (Rat) Background: Lymphotoxin beta Receptor/TNFRSF3 Lymphotoxin beta receptor (LT beta R), also known as TNF C receptor and TNF R2rp, was originally identified as a transcribed sequence with homology to the TNF receptor superfamily. The cytoplasmic region of LT beta R shares little sequence similarity with other TNF receptor family members, suggesting that different signaling mechanisms may be utilized. LT beta R is expressed in a variety of tissues including visceral and lymphoid tissues. The human and mouse LT beta R share 76% amino acid sequence identity.