金山科研平台，产品价格货期咨询微信：jinshanbio Source:Chinese Hamster Ovary cell line, CHO-derived Accession #:P43406 (Integrin alpha V) & Q9Z0T9 (Integrin beta 6) N-terminal Sequence Analysis:Phe31 ( alpha V subunit) & Gly22 ( beta 6 subunit) Structure:Non-covalently-linked heterodimer Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:115 kDa ( alpha V subunit) &82.6 kDa( beta 6 subunit) SDS-PAGE:135-150 kDa & 110-125 kDa, reducing conditions Activity:Measured by its binding ability in a functional ELISA.Immobilized RecombinantMouse Integrin alpha V beta 6 at2.0µg/mL can bind Recombinant Human LAP TGF‑beta 1 (Catalog# 246-LP) with an apparent K_D <0.1nM. Formulation:Lyophilized from a 0.2 µm filtered solution in PBS.See Certificate of Analysis for details. Molecule Information: Integrin alpha V beta 6 Entrez Gene IDs: 3685 (Human) Background: Integrins Integrins are transmembrane proteins that mediate interactions between adhesion molecules on adjacent cells and/or the extracellular matrix (ECM). Integrins have diverse roles in several biological processes including cell migration during development and wound healing, cell differentiation, and apoptosis. Their activities can also regulate the metastatic and invasive potential of tumor cells. They exist as heterodimers consisting of alpha and beta subunits. Some alpha and beta subunits exhibit specificity for one another and may be designated as a VLA (very late antigen) member. Heterodimers often preferentially bind certain cell adhesion molecules, or constituents of the ECM. Although they have no catalytic activity, integrins can be part of multimolecular signaling complexes known as focal adhesions.