金山科研平台，产品价格货期咨询微信：jinshanbio Source:Mouse myeloma cell line, NS0-derived Accession #:NP_034238 N-terminal Sequence Analysis:Gln23 predicted: No results obtained, sequencing might be blocked Structure:Disulfide-linked homodimer Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:48 kDa (monomer) SDS-PAGE:60-66 kDa, reducing conditions Activity:Measured by its ability to inhibit proliferation of PC‑3 human prostate cancer cells.The ED₅₀ for this effect is typically 15-75 ng/mL. Formulation:Lyophilized from a 0.2 µm filtered solution in PBS.See Certificate of Analysis for details. Molecule Information: Ephrin-A3 Aliases: EFL-2; EFNA3; Ehk1-L; LERK3 Entrez Gene IDs: 1944 (Human) Background: Ephrin-A

There are two structural groups of ephrin ligands which bind to a family of receptor tyrosine kinases (Eph). A-type ephrins bind A-type receptors, which are tethered to the cell membrane via a glycosylphosphatidylinositol (GPI) anchor. B-type ephrins bind to B-type receptors, which have a single transmembrane domain and a cytoplasmic region. All ephrin ligands share a conserved extracellular sequence, which most likely corresponds to the receptor binding domain. This conserved sequence consists of approximately 125 amino acids and includes four invariant cysteines.

Only membrane bound or Fc-clustered ephrin ligands are capable of activating the receptor in vitro. Soluble monomeric ephrin ligands bind the receptor but do not induce receptor autophosphorylation and activation. In vivo, ephrin ligands and receptors display reciprocal expression. It has been found that nearly all ephrin receptors and ligands are expressed in developing and adult neural tissue. The Eph/ephrin families also appear to play a role in angiogenesis and synapse formation.