R&D Systems代理671-GP-100 Recombinant Human gp130 Fc Chimera Protein, CF (100 UG)-试剂-金山科研平台

R&D Systems代理671-GP-100 Recombinant Human gp130 Fc Chimera Protein, CF (100 UG)

2025-06-28

货号：671-GP-100

品牌：R&D Systems

规格：100ug

目录价：￥4490.00

市场价格：￥3592.00

会员价格：￥3592.00

到货时间：3~4周

金山科研平台，产品价格货期咨询微信：jinshanbio Source:Mouse myeloma cell line, NS0-derived Accession #:P40189 N-terminal Sequence Analysis:Glu23 Structure:Disulfide-linked homodimer Purity:>90%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:95 kDa (monomer) SDS-PAGE:150 kDa, reducing conditions Activity:Measured by its ability to inhibit the IL-6 R alpha enhancement of IL-6 activity on M1 mouse myeloid leukemia cells. Saito, T. et al. (1991) J. Immunol. 147:168.The ED₅₀ for this effect is typically 0.05-0.15µg/mL in the presence of 10ng/mL rhIL-6sR and 20ng/mL rhIL-6. Formulation:Lyophilized from a 0.2 µm filtered solution in PBS.See Certificate of Analysis for details. Molecule Information: gp130 Long Name: Glycoprotein 130 Aliases: CD130; IL6ST Entrez Gene IDs: 3572 (Human); 16195 (Mouse); 25205 (Rat) Background: gp130

View gp130 IHC images. Gp130, the common signal transducing receptor component shared by the functional receptor complexes of the IL-6 family of cytokines, belongs to the classI cytokine receptor family. Binding of IL-6 or IL-11 to either the membrane-anchored or soluble IL-6 R or IL-11 R, respectively, initiates the association of IL-6 R (IL-11 R) with gp130. The complex then undergoes homodimerization and signal transduction. For other IL-6 family cytokines, such as LIF and OSM, signal transduction is similarly triggered by the heterodimerization of gp130 with LIFR or OSM R.

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