金山科研平台，产品价格货期咨询微信：jinshanbio Source:Chinese Hamster Ovary cell line, CHO-derived, Ala36-Ala342 with and N-terminal human CD33 signal sequence and a C-terminal 6‑His tag Accession #:Q11130 N-terminal Sequence Analysis:Ala36 Purity:>95%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain at 5 µg per lane. Endotoxin Level: Predicted Molecular Mass:36 kDa SDS-PAGE:40-45 kDa, reducing conditions Activity:Measured by its ability to transfer fucose from GDP-fucose to fetal bovine fetuin.The specific activity is >175 pmol/min/µg, as measured under the described conditions. Formulation:Supplied as a 0.2 µm filtered solution in Tris and NaCl.See Certificate of Analysis for details. Molecule Information: Fucosyltransferase 7/FUT7 Aliases: FucT-VII; FUT7 Entrez Gene IDs: 2529 (Human) Background: Fucosyltransferase 7 N-glycans, O-glycans and glycolipids are frequently fucosylated at terminal sites. Therefore, fucose is often part of a sugar epitope with important biological function. Well known fucose containing glycans include Lewis and ABO blood group antigens. Lewis epitopes are key elements involved in the leukocyte homing and extravasation process and thus are important for lymphocyte maturation and natural defense functions. Fucose-containing glycans also play critical roles in cell signaling and development. More than 10 fucosyltransferases have been cloned. FUT1 and FUT2 are alpha1-2 fucosyltransferases and are responsible for ABO blood-group antigen synthesis. FUT8 is an alpha1-6 fucosyltransferase that adds a fucose to the chitobiose core of N-glycans. FUT3, FUT4, FUT5, FUT6, FUT7 and FUT9 are alpha1-3 or alpha1-4 fucosyltransferases and are responsible for Lewis antigen generation. FUT7 plays an exclusive role for the biosynthesis of sialy Lewis X epitope (NeuAc alpha 2,3Gal beta 1,4[Fuc alpha 1,3]GlcNAc) that serves as a ligand in the E-selectin and P-selectin mediated adhesion of leukocytes to activated endothelium or platelets.