货号：12-534

品牌：Merck Millipore

规格：EA

目录价：￥2380.00

市场价格：￥2023.00

会员价格：￥1904.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: INCENP (aa826-919)-GST View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 100 µg View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994 [PubMed 8088460]). These include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 [PubMed 1860899]), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis (Cutts et al., 1999 [PubMed 10369859]).[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: Q9NQS7 # Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Probably acts through association with AURKB or AURKC. Seems to bind directly to microtubules.SIZE: 923 amino acids; 106114 Da SUBUNIT: Homodimer or heterodimer. Interacts with H2AFZ (By similarity). Interacts with CBX3. Interacts with tubulin beta chain. Interacts with AURKB and AURKC. Component of the CPC at least composed of BIRC5/survivin, CDCA8/borealin, INCENP and AURKB/Aurora-B. Interacts with EVI5.SUBCELLULAR LOCATION: Centromere. Spindle. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with AURKB at mitotic chromosomes. View All» Species: Human View All» Quality Assurance: Routinely evaluated for use as a substrate in protein kinase assay. View All» Brand Family: Upstate View All» Presentation: 50mM Tris-HCl, pH 7.5, 50% glycerol, 150mM NaCl, 0.1mM EGTA, 0.1% β-mercaptoethanol, 0.03% Brij-35, 0.2mM PMSF, 1mM benzamidine View All» UniProt Number: Q9NQS7 View All» Storage Conditions: 6 months at -20°C View All» Gene Symbol:

• INCENP

• FLJ31633

• MGC111393
  View All» Product Name: INCENP (aa826-919)-GST View All» Entrez Gene Number:
  • NM_001040694.1

  • NM_020238.2
    View All»
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