金山科研平台，产品价格货期咨询微信：jinshanbio Source:Mouse myeloma cell line, NS0-derived Accession #:NP_035738 N-terminal Sequence Analysis:Met1 Structure:Disulfide-linked homodimer Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:32 kDa (monomer) SDS-PAGE:35-40 kDa, reducing conditions Activity:Measured by its ability to inhibit APRIL-mediated proliferation of anti-IgM stimulated mouse B cells. Moore,P.A. etal. (1999) Science 285:260; Gross, J.A. et al. (2000) Nature 404:995; Schneider,P. etal. (1999) J. Exp. Med. 189:1747.The ED₅₀ for this effect is typically 0.01-0.03 µg/mL in the presence of 100 ng/mL of rhAPRIL. Formulation:Lyophilized from a 0.2 µm filtered solution in MES and NaCl.See Certificate of Analysis for details. Molecule Information: BCMA/TNFRSF17 Long Name: B Cell Maturation Factor Aliases: CD269; TNFRSF17 Entrez Gene IDs: 608 (Human); 21935 (Mouse); 287034 (Rat) Background: BCMA/TNFRSF17 B cell maturation protein (BCMA) is a member of the TNF receptor superfamily (TNFRSF17). BCMA is expressed in immune organs and mature Bcell lines. Although some expression has been observed at the cell surface, BCMA appears to be localized to the Golgi compartment. BCMA binding to APRIL or BAFF stimulates IgM production in peripheral blood B cells and increases the survival of cultured B cells. Mature human and mouse BCMA share 86% amino acid sequence identity.