货号：12-439

品牌：Merck Millipore

规格：500Ug

目录价：￥4285.00

市场价格：￥3642.25

会员价格：￥3428.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Retinoblastoma Protein (aa 773-928) View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 500 µg View All» Product Overview: Recombinant fusion protein containing the C-terminal fragment (residues 773-928) of human retinoblastoma protein (Rb) with an N-terminal His6-tag, expressed in E. coli. View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: Retinoblastoma (RB) is an embryonic malignant neoplasm of retinal origin. It almost always presents in early childhood and is often bilateral. Spontaneous regression ('cure') occurs in some cases. The retinoblastoma gene RB was the first tumor suppressor gene cloned, and is a negative regulator of the cell cycle through its ability to bind the transcription factor E2F (MIM 189971) and repress transcription of genes required for S phase (Hanahan and Weinberg, 2000 [PubMed 10647931]).[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: P06400 # Key regulator of entry into cell division that acts as a tumor suppressor. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Also acts as a transcription repressor of E2F target genes by recruiting chromatin-modifying enzymes to promoters. Inhibits the intrinsic kinase activity of TAF1. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding.SIZE: 928 amino acids; 106159 Da SUBUNIT: Interacts preferentially with transcription factor E2F1. The unphosphorylated form interacts with ARID3B, JARID1A, SUV39H1, MJD2A/JHDM3A and THOC1. Interacts with the N-terminal domain of TAF1. Interacts with AATF, DNMT1, LIN9, LMNA, SUV420H1, SUV420H2, PELP1 and TMPO-alpha. May interact with KNTC2. Interacts with EID1 and ZUBR1. Interacts with ARID4A and JARID1B.SUBCELLULAR LOCATION: Nucleus.TISSUE SPECIFICITY: Expressed in the retina.PTM: Phosphorylated from S to M phase of the cell cycle and is dephosphorylated in G1. T, but not E1A, binds only to the unphosphorylated form.DISEASE: SwissProt: P06400 # Defects in RB1 are the cause of childhood cancer retinoblastoma (RB) [MIM:180200]. RB is a congenital malignant tumor that arises from the nuclear layers of the retina. It occurs in about 1:20'000 live births and represents about 2% of childhood malignancies. It is bilateral in about 30% of cases. Although most RB appear sporadically, about 20% are transmitted as an autosomal dominant trait with incomplete penetrance. The diagnosis is usually made before the age of 2 years when strabismus or a gray to yellow reflex from pupil (cat eye) is investigated. & Defects in RB1 are a cause of bladder cancer [MIM:109800]. & Defects in RB1 are a cause of osteogenic sarcoma [MIM:259500].SIMILARITY: SwissProt: P06400 ## Belongs to the retinoblastoma protein (RB) family. View All» Quality Assurance: Routinely evaluated as a sustrate for many Serine/Threonine kinases. View All» Brand Family: Upstate View All» Presentation: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, and 500 mM imidazole View All» UniProt Number: P06400 View All» Storage Conditions: Stable for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. View All» Gene Symbol:

• RB1

• RB

• PP110

• P105-RB

• retinoblastoma-1

• OSRC
  View All» Product Name: Retinoblastoma Protein (aa 773-928) View All» Entrez Gene Number: NM_000321.2 View All» Concentration: 2.0 mg/mL View All»
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  © Merck Millipore代理12-439 Retinoblastoma Protein (aa 773-928);视网膜母细胞瘤蛋白（aa 773-928）store at -20℃，产品报价联系微信jinshanbio