金山科研平台，产品价格货期咨询微信：jinshanbio Source:Spodoptera frugiperda, Sf 21 (baculovirus)-derived Accession #:BAA05023 N-terminal Sequence Analysis:Ala21 & Thr22 Structure:Disulfide-linked homodimer Purity:>90%, by SDS-PAGE under reducing conditions and visualized by silver stain. Endotoxin Level: Predicted Molecular Mass:37.5 kDa (monomer) SDS-PAGE:40-50 kDa, reducing conditions Activity:Measured by its binding ability in a functional ELISA.When Recombinant Rat Endoglin/CD105 Fc Chimera (Catalog# 6440-EN)or Recombinant Mouse Endoglin/CD105 Fc Chimera (Catalog# 1320-EN)is immobilized at 2 µg/mL (100 µL/well), the concentration of Recombinant Mouse TGF‑beta RI/ALK‑5 Fc Chimera that produces 50%of the optimal binding response is found to be approximately 0.25 - 1.25 µg/mL. Formulation:Lyophilized from a 0.2 µm filtered solution in PBS.See Certificate of Analysis for details. Molecule Information: TGF-beta RI/ALK-5 Long Name: Transforming Growth Factor beta Receptor I Aliases: ALK-5; SKR4; TGFBR1 Entrez Gene IDs: 7046 (Human); 21812 (Mouse); 29591 (Rat) Background: TGF-beta Receptors Most cell types express three sizes of receptors for TGF-beta. These are designated Type I (53 kDa), Type II (70 - 85 kDa), and Type III (250 - 350 kDa). The Type I receptor is a membrane-bound serine/threonine kinase that apparently requires the presence of the Type II receptor to bind TGF-beta. The Type II receptor is also a membrane-bound serine/threonine kinase that binds TGF-beta1 and TGF-beta 3 with high affinity and TGF-beta 2 with much lower affinity. The Type I and Type II receptors together form a heterodimeric signaling complex that is essential for the transduction of the anti-proliferative signals of TGF-beta. The Type III receptor is a transmembrane proteoglycan with a large extracellular domain and a 43 amino acid residue cytoplasmic domain. The cytoplasmic domain of the Type III receptor lacks an obvious signaling motif and the receptor may not be involved directly in signal transduction.