货号：12-421

品牌：Merck Millipore

规格：50Ug

目录价：￥3004.00

市场价格：￥2553.40

会员价格：￥2403.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: MYPT1, (714-1004) View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 50 µg View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. View All» UniProt Summary: FUNCTION: SwissProt: O14974 # Regulates myosin phosphatase activity.SIZE: 1030 amino acids; 115281 Da SUBUNIT: PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, and one or several targeting or regulatory subunits. PPP1R12A mediates binding to myosin. Interacts with ARHA and CIT (By similarity). Binds PPP1R12B, ROCK1 and IL16.SUBCELLULAR LOCATION: Cytoplasm. Note=Along actomyosin filaments and stress fibers.PTM: Phosphorylated by CIT (Rho-associated kinase) (By similarity). Phosphorylated cooperatively by ROCK1 and CDC42BP on Thr-696. Phosphorylated on upon DNA damage, probably by ATM or ATR.SIMILARITY: SwissProt: O14974 ## Contains 6 ANK repeats. View All» Quality Assurance: Routinely evaluated as a substrate for ROKa/ROCK-II, active. View All» Brand Family: Upstate View All» Presentation: 50mM Tris-HCl pH 7.5, 150mM NaCl, 0.1mM EGTA, 0.1% 2-mercaptoethanol, 0.03% Brij-35, 1mM benzamidine, 0.2mM PMSF and 50% glycerol View All» UniProt Number: O14974 View All» Storage Conditions: 1 year at -20°C View All» Gene Symbol:

• PPP1R12A

• MYPT1

• MGC133042

• MBS
  View All» Product Name: MYPT1, (714-1004) View All» Entrez Gene Number: NM_002480.1 View All»
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