货号：12-338

品牌：Merck Millipore

规格：1EA

目录价：￥2069.65

市场价格：￥1759.20

会员价格：￥1655.72

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Wortmannin, (PI3 Kinase inhibitor) View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 1 mg View All» Product Overview: Wortmannin, a fungal metabolite, is a cell-permeable, irreversible inhibitor of phosphatidylinositol 3 kinase (PI3 Kinase) with an IC50 of 5nM. It blocks the catalytic activity of PI3-Kinase without affecting upstream signaling events such as insulin receptor tyrosine kinase activity. Wortmannin also inhibits the activities of myosin light chain kinase and PI4-Kinase at concentrations a hundred times higher than those required to inhibit PI3-Kinase. View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: Receptor-regulated class I phosphoinositide 3-kinases (PI3Ks) phosphorylate the membrane lipid phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) to PtdIns(3,4,5)P3, which in turn recruits and activates cytosolic effectors involved in proliferation, survival, or chemotaxis. PIK3R5 is a PI3K regulatory subunit (Brock et al., 2003 [PubMed 12507995]).[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: Q8WYR1 # Regulatory subunit of the PI3K gamma complex.SIZE: 880 amino acids; 97348 Da SUBUNIT: Heterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit. Interacts with G beta gamma proteins.SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity).TISSUE SPECIFICITY: Highly expressed in leukocytes, followed by spleen, lymph node, thymus ans bone marrow.DOMAIN:SwissProt: Q8WYR1 The heterodimerization region allows the binding to the catalytic subunit. SIMILARITY: View All» Brand Family: Upstate View All» Protein Target: PI3Kγ View All» Presentation: 1mg of lyophilized powder packaged under inert gas. White to off-white powder. View All» Storage Conditions: Protect from light. Stable for 2 years as supplied at -20°C. Following reconstitution aliquot and store at -20°. The DMSO/ethanol stock solutions are stable for 1-3 months at -20°C. View All» Target Sub-Family: PI3K/PI4K View All» Gene Symbol:

• PIK3R5

• P101-PI3K

• FOAP-2

• F730038I15Rik
  View All» Product Name: Wortmannin, (PI3 Kinase inhibitor) View All» Quality Assurance: Routinely evaluated by kinase assay. Purity: ≥95% by HPLC. Molecular Formula: C₂₃H₂₄O₈ Molecular Weight: 428.4 View All» UniProt Number: Q8WYR1 View All» Entrez Gene Number: NM_014308.2 View All»
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