货号：12-240

品牌：Merck Millipore

规格：1EA

目录价：￥3458.93

市场价格：￥2940.09

会员价格：￥2767.14

金山科研平台，产品价格货期咨询微信：jinshanbio Description: MAPKAP Kinase Substrate Peptide View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 1 mg View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. View All» UniProt Summary: FUNCTION: SwissProt: P49137 # Its physiological substrate seems to be the small heat shock protein (HSP27/HSP25). In vitro can phosphorylate glycogen synthase at 'Ser-7' and tyrosine hydroxylase (on 'Ser-19' and 'Ser-40'). This kinase phosphorylates Ser in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue (By similarity). Mediates both ERK and p38 MAPK/MAPK14 dependent neutrophil responses. Participates in TNF alpha-stimulated exocytosis of secretory vesicles in neutrophils. Plays a role in phagocytosis-induced respiratory burst activity.SIZE: 400 amino acids; 45568 Da SUBUNIT: Interacts with PHC2.TISSUE SPECIFICITY: Expressed in all tissues examined.PTM: Phosphorylated and activated by MAP kinase.SIMILARITY: SwissProt: P49137 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. & Contains 1 protein kinase domain. View All» Quality Assurance: Routinely evaluated as a substrate for MAPKAP Kinase 2, active (14-216 & 14-337). May also be used as a substrate for MAPKAP Kinase 1. View All» Brand Family: Upstate View All» Presentation: Lyophilized powder View All» Protein Target: MAPKAP View All» UniProt Number: P49137 View All» Target Sub-Family: CAMK View All» Storage Conditions: Lyophilized: Stable for 2 years at 4°C View All» Gene Symbol:

• MAPKAPK2

• MK2

• MAPKAPK-2
  View All» Product Name: MAPKAP Kinase Substrate Peptide View All» Entrez Gene Number:
  • NM_004759.3

  • NM_032960.2
    View All»
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