金山科研平台，产品价格货期咨询微信：jinshanbio Source:Mouse myeloma cell line, NS0-derived, Leu33-His287, with a C-terminal 6-His tag Accession #:Q91YK8 N-terminal Sequence Analysis:Leu33 Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:27.5 kDa SDS-PAGE:60-80 kDa, reducing conditions Activity:Measured by its binding ability in a functional ELISA.When rmC4.4A/LYPD3 is immobilized at 0.5 µg/mL (100 µL/well), rhGalectin-3 binds with an apparent K_D < 80 nM. Formulation:Lyophilized from a 0.2 µm filtered solution in PBS.See Certificate of Analysis for details. Molecule Information: C4.4A/LYPD3 Long Name: Leucine Rich Repeat and Fibronectin Type III Domain Containing 3 Aliases: LYPD3; MIG-C4 Entrez Gene IDs: 27076 (Human); 72434 (Mouse); 60378 (Rat) Background: C4.4A/LYPD3 C4.4A, also known as LYPD3, is a 65-100 kDa GPI-linked glycoprotein with structural similarity to uPAR. Soluble forms are generated by proteolytic cleavage or released in membrane vesicles. C4.4A is expressed in the suprabasal layers of stratified squamous epithelium, and it is upregulated at the invasive front of melanomas and carcinomas. Metastases derived from these tumors also express high levels of C4.4A. The interaction of C4.4A with Laminin-1 and -5 on neighboring cells promotes the adhesion, spreading, and migration of tumor cells.