金山科研平台，产品价格货期咨询微信：jinshanbio Source:Mouse myeloma cell line, NS0-derived, Ser32-Lys314 Accession #:AAB70793 N-terminal Sequence Analysis:Ser32, Phe39 (minor) & Asp42 (minor) Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:32.6 kDa SDS-PAGE:33-40 kDa, reducing conditions Activity:Measured by its ability to inhibit proliferation of HeLa human cervical epithelial carcinoma cells. Ko, L. et al. (2002) Exp. Cell Res. 280:280.The ED₅₀ for this effect is typically 0.15‑0.75 µg/mL. Formulation:Lyophilized from a 0.2 µm filtered solution in Phosphate and NaCl.See Certificate of Analysis for details. Molecule Information: sFRP-1 Long Name: Secreted Frizzled Related Protein 1 Aliases: FrzA; SARP-2 Entrez Gene IDs: 6422 (Human); 20377 (Mouse); 84402 (Rat) Background: Secreted Frizzled Related Proteins (sFRP) Secreted Frizzled related proteins are secreted glycoproteins with homology to the Wnt-binding domain of the Frizzled family of transmembrane receptors. sFRPs contain an N-terminal Frizzled-like cysteine-rich domain (CRD) with 10 conserved cysteines and a C-terminal heparin-binding region. sFRPs function as soluble antagonists of Wnt signaling by binding directly to Wnt proteins and preventing their interactions with Frizzled receptors.