货号：09-872

品牌：Merck Millipore

规格：

目录价：￥5657.00

市场价格：￥4808.45

会员价格：￥4525.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Methylcytosine dioxygenase TET1 Antibody | 09-872 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes methylcytosine dioxygenase TET1 near the C-terminus. View All» Molecular Weight: ~220 kDa observed. Uncharacterized bands may be seen at ~32, 68, and 70 kDa. View All» Epitope: Near the C-terminus View All» Immunogen: KLH-conjugated linear peptide corresponding to mouse Methylcytosine dioxygenase TET1 near the C-terminus. View All» Background Information: Methylcytosine dioxygenase TET1 (mTET1) is a member of the TET family and contains a characteristic CXXC-type zinc finger domain. mTET1 binds methylcytosine (5mC), a minor, mammalian DNA base necessary to development and retrotransposon silencing, and acts as a catalyst to induce the conversion of 5mC to 5-hydromethylcytosine (hmC or 5hmC), a mammalian DNA base thought to be involved in chromatin structure and in the development of fetal brain, heart and lung tissues. Recent studies indicate that mTET1 regulates the levels of 5hmC, thereby influencing patterns in DNA methylation. View All» Species Reactivity: Mouse View All» Species Reactivity Note: Demonstrated to react with mouse. Other homologies: Rat (66% sequence homology), Human (61% sequence homology). View All» Application Notes: Western Blot (Snap i.d.) Analysis: 5 µg/mL from a previous lot detected Methylcytosine dioxygenase TET1 in 10 µg of mouse embryonic stem cell lysate. View All» Control: Mouse embryonic stem cell lysate View All» Quality Assurance: Evaluated by Western Blot in mouse embryonic stem cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected Methylcytosine dioxygenase TET1 in 10 µg of mouse embryonic stem cell lysate. View All» Purification Method: Affinity Purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q3URK3 View All» Entrez Gene Number: NP_081660 View All» Gene Symbol:

• TET1

• LCX1

• CXXC6
  View All» Alternate Names:
  • tet oncogene 1

  • Ten-eleven translocation 1 gene protein

  • CXXC-type zinc finger protein 6

  • methylcytosine dioxygenase TET1

  • CXXC finger 6

  • ten-eleven translocation-1

  • Leukemia-associated protein with a CXXC domain
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • ChIP-seq
      View All» UniProt Summary: FUNCTION: Dioxygenase that specifically binds methylcytosine (5mC), a minor base in mammalian DNA found in repetitive DNA elements that is crucial for retrotransposon silencing and mammalian development. Catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (hmC). The clear function of 5-hydroxymethylcytosine (hmC) is still unclear but it may influence chromatin structure and recruit specific factors or may constitute an intermediate component in cytosine demethylation. 5-hydroxymethylcytosine (hmC) is present in ES cells and is enriched in the brain, especially in Purkinje neurons. May play a role in the fetal development of heart, lung and brain (By similarity).CATALYTIC ACTIVITY: Methylcytosine + 2-oxoglutarate + O2 = 5-hydroxymethylcytosine + succinate + CO2.COFACTOR: Binds 1 Fe2+ ion per subunit (By similarity).SUBCELLULAR LOCATION: Nucleus (By similarity). SEQUENCE SIMILARITIES: Belongs to the TET family.Contains 1 CXXC-type zinc finger.SEQUENCE CAUTION: The sequence BAB27288.1 differs from that shown. Reason: Erroneous initiation. View All» Product Name: Anti-Methylcytosine dioxygenase TET1 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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