金山科研平台，产品价格货期咨询微信：jinshanbio Source:Mouse myeloma cell line, NS0-derived Accession #:AAH57856 N-terminal Sequence Analysis:Arg21 Structure:Disulfide-linked homodimer Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Endotoxin Level: Predicted Molecular Mass:50.6 kDa (monomer) SDS-PAGE:62-70 kDa, reducing conditions Activity:Measured by its binding ability in a functional ELISA.1 µg/mL of rmIL-28 R alpha Fc Chimera was mixed with serially diluted rmIL-28B (Catalog # 1789-ML). Following incubation, the IL-28 R alpha rmIL-28B complex was captured in a goat anti-mFc-coated plate. Bound IL-28B was measured using biotinylated goat anti-mIL-28B.The concentration of rmIL-28B that produces 50% of the optimal binding was found to be approximately 0.7 - 3.5 µg/mL. Formulation:Lyophilized from a 0.2 µm filtered solution in PBS.See Certificate of Analysis for details. Molecule Information: IL-28 R alpha/IFN-lambda R1 Long Name: Interleukin 28 Receptor alpha Aliases: CRF2-12; IFN-lambda R1; IFNLR1; IL28RA; LICR2 Entrez Gene IDs: 163702 (Human); 242700 (Mouse); 362628 (Rat) Background: IL-28 R alpha IL-28 receptor alpha subunit, also named interferon-lambda R1, is a type I transmembrane glycoprotein that is cytokine receptor family 2 member 12 (CRF2-12). It pairs with the IL-10 receptor beta subunit (IL-10 R beta, CRF2-4) to form the IL-28 R. This receptor interacts with the interferon-like cytokines (type III interferons) IL-28A (IFN-lambda 2), IL-28B (IFN-lambda 3) and IL-29 (IFN-lambda 1). Signaling through IL-28 R alpha results in upregulated expression of MHC class I antigens and anti-viral, anti-proliferative and anti-tumor activity.