货号：09-846

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-UBE2T Antibody | 09-846 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes UBE2T. View All» Molecular Weight: ~28 kDa View All» Epitope: a.a. 148-197 View All» Immunogen: GST-tagged UBE2T fusion protein corresponding to a.a. 148-197 of human Ube2T. View All» Background Information: The covalent conjugation of ubiquitin to proteins regulates diverse cellular pathways and proteins. Ubiquitin is transferred to a target protein through the concerted action of an ubiquitin-activating enzyme (E1), an ubiquitin-conjugating enzyme (E2), and an ubiquitin ligase (E3)UBE2T (Ubiquitin-conjugating enzyme E2 T), a member of the ubiquitin-conjugating E2 family, is involved in the monoubiquitination of the FANCD2 protein, which is part of the Fanconi anemia core complex required for the efficient repair of damaged DNA. Recent studies have shown that UBE2T is significantly upregulated in lung cancer tissue and cell lines, suggesting involvement of UBE2T in the malignant cell phenotype. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Human and mouse. Detected in A431, HEK293, HeLa, Jurkat, and PC3 cell lines, and human heart tissue , but not detected in C2C12, HepG2, HUVEC, L6, NIH/3T3, RAW264.7, or PC12 cell lines. View All» Control: HEK293 lysate View All» Quality Assurance: Western Blot Analysis: : 1:1000 dilution of this antibody detected UBE2T on 10 µg of HEK293 cell lysate. View All» Presentation: Rabbit polyclonal serum with 0.05% NaN3. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: Q9NPD8 View All» Entrez Gene Number: NP_054895.1 View All» Gene Symbol:
  • HSPC150

  • PIG50

  • EC 6.3.2.19

  • OTTHUMP00000038808
    View All» Alternate Names:
    • HSPC150 protein similar to ubiquitin-conjugating enzyme

    • Ubiquitin carrier protein T

    • Ubiquitin-protein ligase T

    • ubiquitin conjugating enzyme

    • ubiquitin-conjugating enzyme E2T (putative)
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The covalent conjugation of ubiquitin to proteins regulates diverse cellular pathways and proteins. Ubiquitin is transferred to a target protein through a concerted action of a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), such as UBE2T, and a ubiquitin ligase (E3) (Machida et al., 2006 [PubMed 16916645]).[supplied by OMIM]. View All» UniProt Summary: FUNCTION: Catalyzes the covalent attachment of ubiquitin to other proteins By similarity.Catalytic activity ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PATHWAY PROTEIN MODIFICATION: protein ubiquitination.SIMILARITY:Belongs to the ubiquitin-conjugating enzyme family View All» Product Name: Anti-UBE2T Antibody | 09-846 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μL View All» Format: Serum View All» Host: Rabbit View All»
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