金山科研平台，产品价格货期咨询微信：jinshanbio Source:Mouse myeloma cell line, NS0-derived, Arg30-Thr851, with a C-terminal 6-His tag Accession #:AAH33902 N-terminal Sequence Analysis:Arg30 Structure:Monomer Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:92.8 kDa SDS-PAGE:110-120 kDa, reducing conditions Activity:Measured by the ability of the immobilized protein to support the adhesion of Neuro‑2A mouse neuroblastoma cells.The ED₅₀ for this effect is typically1-4µg/mL.Optimal dilutions should be determined by each laboratory for each application. Formulation:Lyophilized from a 0.2 µm filtered solution in PBS.See Certificate of Analysis for details. Molecule Information: Calsyntenin-1 Aliases: Alcadein-alpha; CLSTN1; CS1; CSTN1; XB31alpha Entrez Gene IDs: 22883 (Human); 65945 (Mouse); 313717 (Rat) Background: Calcyntenin-1

Calsyntenin-1 (CST-1; also Alcadein-alpha) is a 140 - 150 kDa member of the Alcadein family of molecules. It is expressed in the ER/Golgi and on the plasma membranes of almost all neurons. Calsyntenin-1 is a calcium-binding protein that may regulate post-synaptic signaling and Amyloid Precursor Protein (APP) cleavage and gene activation. Notably, when cleaved in a manner similar to APP, its intracellular fragment antagonizes APP AICD gene activation.

Mature human CST-1 is a 953 amino acid (aa) type I transmembrane protein. It contains two cadherin domains (aa 38 - 265) in its extracellular region (aa 29 - 859) and a 101 aa cytoplasmic tail. Extracellular cleavage occurs at Met825 Ala826, generating a soluble 115 kDa ECD. Isoforms involve a 78 aa substitution for aa 917 - 981, plus deletions of aa 72 - 81 and 507 - 525. Over aa 30 - 851, human CST-1 shares 92% aa identity with mouse CST-1.