货号：09-817

品牌：Merck Millipore

规格：100Ug

目录价：￥5974.00

市场价格：￥5077.90

会员价格：￥4779.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-JMJD1C Antibody | 09-817 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~284 kDa observed View All» Epitope: 0 View All» Immunogen: KLH-conjugated linear peptide corresponding to human JMJD1C. View All» Background Information: JMJD1C (jumonji domain-containing protein 1C) is also known as TRIP8 and mutations in this histone demethylase have been linked to certain forms of autism. JMJD1C is also thought to work in reactivating genes in embryonic stem cells, pancreatic islet and gastric cancer. JMJD1C has also been implicated as a gene expression regulator. JMJD1C with WHISTLE have recently been shown to also play a role in mouse testis development. JMJD1C has been identified as a nuclear-receptor coactivator and is a candidate gene for autism. View All» Species Reactivity:

• Human

• Rabbit

• Chimpanzee

• Rhesus Macaque
  View All» Species Reactivity Note: Demonstrated to react with Human. Predicted to react with Rabbit, Chimpanzee, Rhesus Macaque, and Orangutan based on 100% sequence homology. View All» Application Notes: Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected JMJD1C in HeLa cells. View All» Control: HeLa nuclear extract View All» Quality Assurance: Evaluated by Western Blot in HeLa nuclear extract.Western Blot Analysis: 1 µg/mL of this antibody detected JMJD1C on 10 µg of HeLa nuclear extract. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q15652 View All» Entrez Gene Number: NP_116165 View All» Gene Symbol:
  • TRIP8

  • RP11-10C13.2

  • JMJD1C

  • JHDM2C
    View All» Alternate Names:
    • JMJD

    • jumonji domain containing 1C

    • TR-interacting protein 8

    • thyroid receptor interacting protein 8

    • probable JmjC domain-containing histone demethylation protein 2C

    • thyroid hormone receptor interactor 8

    • Thyroid receptor-interacting protein 8

    • Jumonji domain-containing protein 1C
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry
        View All» UniProt Summary: FUNCTION: Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity).COFACTOR: Binds 1 Fe2+ ion per subunit (By similarity).SUBUNIT STRUCTURE: Interacts specifically with the ligand-binding domain of the thyroid receptor (TR). Requires the presence of thyroid hormone for its interaction. SUBCELLULAR LOCATION: Nucleus (By similarity). DOMAIN: Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors (By similarity).PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SEQUENCE SIMILARITIES: Belongs to the JHDM2 histone demethylase family.Contains 1 JmjC domain.SEQUENCE CAUTION: The sequence AAC41741.1 differs from that shown. Reason: Frameshift at position 2171. The sequence CAD97921.1 differs from that shown. Reason: Frameshift at position 1697. The sequence CAI10947.1 differs from that shown. Reason: Erroneous gene model prediction. View All» Product Name: Anti-JMJD1C View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
        © 金山科研平台是专业的授权总代理区域代理经销平台。
        © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
        © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
        © 本文地址：https://16ao.com/thread-136860.htm
        © Merck Millipore代理09-817 Anti-JMJD1C Antibody;store at +2℃ to +8℃，产品报价联系微信jinshanbio