货号：09-709

品牌：Merck Millipore

规格：EA

目录价：￥3468.00

市场价格：￥2947.80

会员价格：￥2774.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Retinoid X Receptor γ (RXRG) Antibody | 09-709 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the N-terminal region of RXRG. View All» Molecular Weight: Isoform 1 calculated at ~51 kDa. Isoform 2 calculated at ~35 kDa. View All» Epitope: N-terminus View All» Immunogen: KLH-conjugated linear peptide corresponding to human RXRG at and around the N-terminus. View All» Background Information: RXRG, Retinoid X receptor γ (RXRG or RXR gamma) is a nuclear receptor that mediates the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. RXRs have 3 isoforms: RXRα, RXRβ, and RXRγ. RXRα and RXRβ are widely expressed in the developing embryo and adult, while RXRγ is expressed in the developing pituitary gland, liver, lung, kidney, and heart. RXR's as a whole exert their action by binding, as homodimers or heterodimers, to specific sequences in the promoters of target genes and regulate their transcription. Diseases assoicated with RXRG are diabetic nephripathy and pituitary adenomas. View All» Species Reactivity:

• Human

• Rat

• Mouse
  View All» Species Reactivity Note: Proven to react with human, mouse, and rat. View All» Control: HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot in HeLa cell lysate.Western Blot Analysis: 3 µg/mL of this antibody detected RXRG on 10 µg of HeLa cell lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P48443 View All» Entrez Gene Number: NP_008848.1 View All» Gene Symbol:
  • RXRC

  • RXRG

  • NR2B3
    View All» Alternate Names:
    • Nuclear receptor subfamily 2 group B member 3

    • Retinoid X receptor gamma

    • retinoic acid receptor RXR-gamma

    • retinoid X receptor, gamma

    • retinoid X receptor-gamma
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Nuclear hormone receptor. Involved in the retinoic acid response pathway. Binds 9-cis retinoic acid (9C-RA) By similarity.SUBCELLULAR LOCATION: Nucleus By similarity. DOMAIN: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain By similarity.SEQUENCE SIMILARITIES: Belongs to the nuclear hormone receptor family. NR2 subfamily.Contains 1 nuclear receptor DNA-binding domain. View All» Product Name: Anti-Retinoid X Receptor γ (RXRG) View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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