货号：09-495

品牌：Merck Millipore

规格：

目录价：￥3724.00

市场价格：￥3165.40

会员价格：￥2979.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho LKB1 (Ser431) Antibody | 09-495 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes LKB1 when phosphorylated at Ser431. View All» Molecular Weight: ~ 55 kDa observed View All» Epitope: Phosphorylated Ser431 View All» Immunogen: KLH-conjugated linear peptide corresponding to human LKB1 when phosphorylated at Ser431. View All» Modifications: Phosphorylation View All» Background Information: LKB1 is a serine-threonine protein kinase and member of the calcium calmodulin family. LKB1 acts as a tumor suppressor and plays an important role in the regulation of many cellular processes. It is expressed in all tissues including pancreatic, liver, testicular, cardiac, and skeletal muscle tissue. Mutations in LKB1 result from unregulated cell growth and tumor formation that are associated with Peutz-Jehgers syndrome. View All» Species Reactivity:

• Mouse

• Human

• Rat

• Bovine

• Horse
  View All» Species Reactivity Note: Demonstrated to react with mouse. Predicted to react with human, rat, bovine, and equine based on 100% sequence homology. View All» Application Notes: Western Blot (Snap i.d.®) Analysis: 0.5 µg/mL from a previous lot detected LKB1 on 10 µg of NIH/3T3 treated with forskolin lysate. View All» Control: NIH/3T3 cell lysate View All» Quality Assurance: Evaluated by Western Blot in NIH/3T3 cell lysate.Western Blot Analysis: 0.1 µg/mL of this antibody detected LKB1 on 10 µg of NIH/3T3 cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9WTK7 View All» Entrez Gene Number: NP_035622 View All» Gene Symbol:
  • STK11

  • LKB1

  • PJS
    View All» Alternate Names:
    • Renal carcinoma antigen NY-REN-19

    • Serine/threonine-protein kinase LKB1

    • polarization-related protein LKB1

    • serine/threonine kinase 11

    • erine/threonine kinase 11 (Peutz-Jeghers syndrome)

    • serine/threonine protein kinase 11
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases By similarity. Tumor suppressor. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. UniProtKB Q15831COFACTOR: Magnesium or Manganese (By similarity). UniProtKB Q15831ENZYME REGULATION: Activated by binding of a complex consisting of CAB39 and STRAD or CAB39 and ALS2CR2 By similarity. UniProtKB Q15831SUBUNIT STRUCTURE: Found in a ternary complex composed of SMAD4, STK11 and STK11IP. Interacts with SMAD4, STK11IP and WDR6 (By similarity).SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note: Relocates to the cytoplasm when bound to CAB39 and STRAD or CAB39 and ALS2CR2. DEVELOPMENTAL STAGE: Ubiquitously expressed 7-11 dpc. Present in nucleated embryonic blood cells from 9 dpc. Restricted to gastrointestinal tract, testis and lung from days 15-19 dpc. DISRUPTION: phenotype Mice die in utero 8.5 to 9.5 dpc due to developmental retardation. Heterozygous mice develop multiple gastric adenomatous polyps. SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.Contains 1 protein kinase domain. View All» Product Name: Anti-phospho LKB1 (Ser431) View All» Concentration: 0.25 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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