货号：09-492

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-Glycogen Synthase (Ser727) Antibody | 09-492 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes human Glycogen Synthase phosphorylated at and around Ser727. View All» Molecular Weight: ~ 84 kDa View All» Epitope: Ser727 View All» Immunogen: KLH-conjugated linear peptide corresponding to human Glycogen Synthase phosphorylated at and around Ser727. View All» Modifications: Phosphorylation View All» Background Information: A glycosyltransferase enzyme that catalyses the reaction of UDP-glucose and (1,4-α-D-glucosyl)n to yield UDP and (1,4-α-D-glucosyl)n+1. In other words, this enzyme converts excess glucose residues one by one into a polymeric chain for storage as glycogen. The reaction is highly regulated by allosteric effectors such as glucose-6-phosphate, by phosphorylation reactions, and indirectly triggered by the hormone insulin. View All» Species Reactivity:

• Mouse

• Human

• Rat
  View All» Species Reactivity Note: Reacts with mouse. Predicted to react with human and rat based on 100% sequence homology. View All» Control: Pervanadate treated and untreated C2C12 cell lysate View All» Quality Assurance: Evaluated by Western Blot in pervanadate treated and untreated C2C12 cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected Glycogen Synthase on 10 µL of pervanadate treated and untreated C2C12 cell lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P13807 View All» Entrez Gene Number: NP_002094 View All» Gene Symbol:
  • GYS1

  • GSY

  • GYS
    View All» Alternate Names: glycogen synthase 1 (muscle) View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene catalyzes the addition of glucose monomers to the growing glycogen molecule through the formation of alpha-1,4-glycoside linkages. Mutations in this gene are associated with muscle glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. View All» UniProt Summary: FUNCTION: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. CATALYTIC ACTIVITY: UDP-glucose ((1->4)-alpha-D-glucosyl)(n) = UDP + ((1->4)-alpha-D-glucosyl)(n+1). ENZYME REGULATION: Allosteric activation by glucose-6-phosphate. Phosphorylation reduces the activity towards UDP-glucose. When in the non-phosphorylated state, glycogen synthase does not require glucose-6-phosphate as an allosteric activator; when phosphorylated it does (By similarity). PATHWAY: Glycan biosynthesis; glycogen biosynthesis. DISEASE: Defects in GYS1 are the cause of muscle glycogen storage disease type 0 (GSD0b) [MIM:611556]; also called muscle glycogen synthase deficiency. GSD0 is a metabolic disorder characterized by fasting hypoglycemia presenting in infancy or early childhood. The role of muscle glycogen is to provide critical energy during bursts of activity and sustained muscle work. SIMILARITY: Belongs to the mammalian/fungal glycogen synthase family. View All» Product Name: Anti-phospho-Glycogen Synthase (Ser727) View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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