货号：09-454

品牌：Merck Millipore

规格：100Ug

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Dock2 Antibody | 09-454 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: 09-454 recognizes mouse DOCK2. View All» Molecular Weight: 180 kDa View All» Epitope: Internal region View All» Immunogen: KLH-conjugated synthetic peptide near amino acid 1730, within the internal region of mouse DOCK2. View All» Isotype: IgG View All» Background Information: Dock2 (Dedicator of cytokinesis 2), is a large protein involved in intracellular signaling networks and a member of the DOCK-A subfamily which function as activators of small G proteins. Dock2 specifically activates isoforms of the small G protein Rac and appears to be expressed specifically in leukocytes. These cells express both Rac1 and Rac2 and Dock2 has been shown to bind and promote nucleotide exchange on both of these isoforms. (Nishihara, 1999) View All» Species Reactivity:

• Human

• Mouse

• Horse

• Primate
  View All» Species Reactivity Note: Mouse. Predicted to cross react with human, equine, and primate, based on 93% sequence homology (13/14 aa). The sequence is 85.7% homologous in rat. Reactivity with other species has not been tested. View All» Control: Mouse spleen lysate View All» Quality Assurance: Evaluated by Western blot on mouse spleen lysate 0.5 μg/mL of Anti-DOCK2 at 1 mg/mL. View All» Purification Method: Peptide affinity purified View All» Presentation: Purified in PBS containing 0.05% NaN3. View All» Storage Conditions: Maintain at 2-8°C for up to 1 year from date of receipt. View All» UniProt Number: Q8C3J5 View All» Entrez Gene Number: NM_004946.2 View All» Gene Symbol:
  • FLJ46592

  • KIAA0209
    View All» Alternate Names:
    • dedicator of cyto-kinesis 2

    • dedicator of cytokinesis 2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The DOCK2 gene encodes a hematopoietic cell-specific CDM family protein that is indispensable for lymphocyte chemotaxis.[supplied by OMIM] View All» UniProt Summary: FUNCTION: Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2 small GTPases, probably by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May participate in IL2 transcriptional activation via the activation of RAC2. Ref.1SUBUNIT: Interacts with RAC1 and RAC2. Interacts with CRKL and VAV. Interacts with CD3Z By similarity.SUBCELLULAR LOCATION: Intracytoplasmic membrane; Peripheral membrane proteinBy similarity. Cytoplasm › cytoskeletonBy similarity. Note= Colocalizes with F-actin By similarity.TISSUE SPECIFICITY: Specifically expressed in hematopoietic cells. Ref.1DOMAIN: The DHR-2 domain probably mediates the GEF activity By similarity.SIMILARITY: Belongs to the DOCK family.Contains 1 DHR-1 (CZH-1) domain.Contains 1 DHR-2 (CZH-2) domain.Contains 1 SH3 domain. View All» Product Name: Anti-Dock2 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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