金山科研平台，产品价格货期咨询微信：jinshanbio Source:Chinese Hamster Ovary cell line, CHO-derived Accession #:NP_035058 N-terminal Sequence Analysis:Leu26 Structure:Disulfide-linked homodimer Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:80.8 kDa (monomer) SDS-PAGE:105-120 kDa, reducing conditions Activity:Measured by its binding ability in a functional ELISA.Immobilized rmNotch-2/Fc Chimera at 5 µg/mL (100 µL/well) can bind rrJagged-1/Fc Chimera with an apparent K_D<5nM. Formulation:Lyophilized from a 0.2 µm filtered solution in PBS and EDTA.See Certificate of Analysis for details. Molecule Information: Notch-2 Entrez Gene IDs: 4853 (Human); 29492 (Rat) Background: Notch-2

The four mammalian Notch receptors appear to have distinct functions, since they do not compensate for one another in genetic studies. Mutations in Notch receptors also lead to specific developmental disorders. For example, Notch-3 is predominantly expressed in the developing central nervous system of mice. Mutations in Notch-3 in humans cause an autosomal dominant condition called CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy). This disorder is characterized by recurrent ischemic strokes at an early age without any underlying vascular risk and progressive dementia.