金山科研平台，产品价格货期咨询微信：jinshanbio Source:Mouse myeloma cell line, NS0-derived, Asn21-Pro235, with a C-terminal 6-His tag Accession #:Q8R1R4.1 N-terminal Sequence Analysis:Asn21 Structure:Noncovalently-linked homodimer Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:25.4 kDa SDS-PAGE:35-40 kDa, reducing conditions Activity:Measured in a cell proliferation assay using NFS‑60 mouse myelogenous leukemia lymphoblast cells.The ED₅₀ for this effect is typically 10-40ng/mL. Molecule Information: IL-34 Long Name: Interleukin 34 Aliases: C16orf77 Entrez Gene IDs: 146433 (Human); 76527 (Mouse) Background: IL-34

Interleukin 34 (IL-34; also known as uncharacterized protein C16orf77) is secreted as a homodimer consisting of 39 kDa monomers. It belongs to no known cytokine family. Human IL-34 is synthesized as a 242 amino acid (aa) precursor that contains a 20 aa signal sequence and a 222 aa mature chain. The mature chain contains one potential site of N-linked glycosylation. Human IL-34 is 71% identical to mouse IL-34 on the amino acid level.

IL-34 is expressed in various tissues, including the heart, brain, liver, kidney, spleen, thymus, testes, ovary, small intestine, prostate, and colon, and is most abundant in the spleen . The receptor for IL-34 is colony-stimulating factor 1 receptor (CSF-1R). IL-34 stimulates monocyte proliferation. In functional studies, IL-34, like CSF-1, the other ligand for CSF-1R, stimulated phosphorylation of extracellular signal-regulated kinase-1 and -2 (ERK1/2) in human monocytes. In addition, IL-34 promoted the formation of the colony-forming unit-macrophage (CFU-M), a macrophage progenitor, in human bone marrow cultures.