货号：09-257

品牌：Merck Millipore

规格：EA

目录价：￥3796.00

市场价格：￥3226.60

会员价格：￥3036.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-PAK1 (Ser204) Antibody | 09-257 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes PAK1 phosphorylated on Ser204 (human)/ Ser203 (mouse). View All» Molecular Weight: 65 kDa View All» Epitope: Ser204 (Central) View All» Immunogen: KLH-conjugated, synthetic phospho-peptide corresponding to residues surrounding phosphorylated Ser204 of human PAK1. View All» Modifications: Phosphorylation View All» Background Information: p21-activated kinases (PAK) are Ser/Thr kinases, which are activated by, and are effectors of Rho family of GTPases. As such, they are implicated in Actin polymerization and activation of the stress-activated kinase cascades. PAK1 is phosphorylated by cdk5, resulting in its inhibition. PAK2 can be activated by Caspase-cleavage in addition to p21-binding, implicating it in cytoskeletal changes during apoptosis. PAK3 is expressed at high levels in post-mitotic neurons of the developing post-natal cerebral cortex and hippocampus, and is the mutant gene thought responsible for non-syndromic X-linked mental retardation. View All» Species Reactivity: Mouse View All» Species Reactivity Note: Human and Rat expected to react based on 100% homology of immunogen. View All» Quality Assurance: Routinely evaluated by western blot on untreated and pervanadate-treated NIH/3T3 cell lysates. View All» Purification Method: Double affinity purification over both non-phospho-peptide column followed by phopshorylated peptide column. View All» Presentation: Affinity purified rabbit polyclonal IgG in storage buffer containing PBS with 0.05% sodium azide in 50% glycerol View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt. View All» UniProt Number: Q13153 View All» Entrez Gene Number: NP_002567 View All» Gene Symbol:

• PAK1

• MGC130001

• Alpha-PAK

• MGC130000

• PAK-1

• PAKalpha

• p65-PAK

• EC 2.7.11.1

• p21-activated kinase 1

• p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)

• p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related)

• Serine/threonine-protein kinase PAK 1
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: PAK proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. These proteins serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK1 regulates cell motility and morphology. Alternativelt spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] View All» UniProt Summary: FUNCTION: The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.SIZE: 545 amino acids; 60647 Da ENZYME REGULATION: Activated by binding small G proteins. Binding of GTP-bound CDC42 or RAC1 to the autoregulatory region releases monomers from the autoinhibited dimer, enables phosphorylation of Thr-423 and allows the kinase domain to adopt an active structure. Also activated by binding to GTP-bound CDC42, independent of the phosphorylation state of Thr-423. Phosphorylation of Thr-84 by OXSR1 inhibits this activationSUBUNIT: Homodimer in its autoinhibited state. Active as monomer. Interacts tightly with GTP-bound but not GDP-bound CDC42/P21 and RAC1. Binds to the caspase-cleaved p110 isoform of CDC2L1 and CDC2L2, p110C, but not the full-length proteins. Component of cytoplasmic complexes, which also contain PXN, ARHGEF6 and GIT1. Interacts with ARHGEF7. Also interacts with CRIPAK.SUBCELLULAR LOCATION: Cytoplasm. Cell junction, focal adhesion. Note=Recruited to focal adhesions upon activation.PTM: Autophosphorylated when activated by CDC42/p21 and RAC1.SIMILARITY: SwissProt: Q13153 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. & Contains 1 CRIB domain. & Contains 1 protein kinase domain. View All» Brand Family: Upstate View All» Product Name: Anti-phospho-PAK1 (Ser204) View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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