金山科研平台，产品价格货期咨询微信：jinshanbio Source:Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Ser78-Ile211 Accession #:Q07731 N-terminal Sequence Analysis:Ser78 Structure:Disulfide-linked homodimer Purity:>97%, by SDS-PAGE under reducing conditions and visualized by silver stain. Endotoxin Level: Predicted Molecular Mass:15 kDa (monomer) Activity:Measured by its ability to support the survival and stimulate neurite outgrowth of dissociated chick embryonic dorsal root ganglia (DRG) neurons. Davies,A.M. (1989) in Neurotrophic Factor Bioassay Using Dissociated Neurons, Nerve Growth Factor. Rush,R.A. (eds): John Willey and Sons, Ltd. 95.The ED₅₀ for this effect is typically 1 - 3 ng/mL.Measured by its binding ability in a functional ELISA.Immobilized Recombinant Rat GFR alpha ‑1/GDNF R alpha ‑1 Fc Chimera (Catalog# 560-GR) at1 µg/mL binds Recombinant Rat GDNF with an apparent K_D <4 nM. Molecule Information: GDNF Long Name: Glial Cell line-derived Growth Factor Entrez Gene IDs: 2668 (Human); 25453 (Rat) Background: GDNF View GDNF IHC images. Glial Cell Line-derived Neurotrophic Factor (GDNF) is a neurotrophic factor that has been shown to promote the survival of various neuronal subpopulations in both the central as well as the peripheral nervous systems at different stages of their development. Neuronal subpopulations that have been shown to be affected by GDNF include motoneurons, midbrain dopaminergic neurons, Purkinje cells and sympathetic neurons. Native GDNF, a disulfide-linked homodimeric glycoprotein, is a novel member of the TGF-β superfamily. Human GDNF cDNA encodes a 211 amino acid residue prepropeptide that is processed to yield a dimeric protein. Mature human GDNF was predicted to contain two 134 amino acid residue subunits. Cells known to express GDNF include Sertoli cells, type 1 astrocytes, Schwann cells, neurons, pinealocytes and skeletal muscle cells.