R&D Systems代理5112-CH-050 Recombinant Human Chitinase 3-like 2 Protein, CF (50 UG)

2025-06-28

货号:5112-CH-050

品牌:R&D Systems

规格:50ug

目录价:¥4490.00

市场价格:¥3592.00

会员价格:¥3592.00

  • 到货时间:3~4周

    金山科研平台,产品价格货期咨询微信:jinshanbio Source:Mouse myeloma cell line, NS0-derived, Tyr27-Leu390, with a C-terminal 10-His tag Accession #:Q15782 N-terminal Sequence Analysis:Tyr27 Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:42.2 kDa SDS-PAGE:40 kDa, reducing conditions Activity:Measured by the ability of the immobilized protein to support the adhesion of FaDu human squamous cell carcinoma cells.

    When 5 x 104 cells per well are added to rhCHI3L2 coated plates for 30 minutes at 37°C, cell adhesion is enhanced in a dose dependent manner with typical ED50range of0.7 - 2.8 µg/mL.

    Opitimal dilutions should be determined by each laboratory for each application.

    Formulation:Lyophilized from a 0.2 µm filtered solution in PBS.See Certificate of Analysis for details. Molecule Information: Chitinase 3-like 2 Aliases: CHI3L2; YKL39 Entrez Gene IDs: 1117 (Human) Background: Chitinase 3-like 2 Chitinase 3-like 2 (CHI3L2), also called chrondrocyte protein 39 or YKL-39, is a 39 kDa potentially glycosylated protein belonging to the family of chitinase-like lectins. These proteins are structurally related to the glycosylhydrolase family 18, but lack enzymatic activity. It is secreted by synovial fibroblasts, chondrocytes, and TGF beta/IL-4-stimulated monocyte-derived macrophages. CHI3L2 expression in synovium correlates with osteoarthritic cartilage degeneration, and is a potential biomarker for osteoarthritis.

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