货号：09-187

品牌：Merck Millipore

规格：

目录价：￥3346.00

市场价格：￥2844.10

会员价格：￥2676.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Ras Antibody, H Palmitoylated | 09-187 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody detects the hypervariable region Ras, H Palmitoylated. View All» Molecular Weight: ~48 kDa (Speculated to have specificity for dimerized form) View All» Epitope: hypervariable region View All» Immunogen: KLH-conjugated synthetic linear peptide corresponding to the hypervariable region of Ras, H, palmitoylated. View All» Background Information: Ras proteins function as GDP/GTP-regulated binary switches in signal transduction cascades that can lead to cell growth, proliferation, differentiation, or survival. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. This Ras superfamily has at least five major branches that include Ras, Rho, Ran, Arf/Sar, Rab. Ras itself has 3 primary isoforms (H-Ras, N-Ras, and K-Ras) that differ in their approximately 20 C-terminal amino acids. They are collectively referred to as Ras. In its active form, Ras is bound to GTP. This causes a conformational change that allow it to interact and bind to several effector molecules, most notably the members of the Raf family, the RalGDS family, and Phosphoinositide 3-kinases (PI3 Kinase). Ras then cleaves GTP to GDP resulting in its inactivation. In its oncogenic, mutated state, Ras is unable to hydrolyze GTP to GDP, thus staying in an active state and activating numerous pathways. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Chicken
  View All» Species Reactivity Note: Human. Expected to react with Rat, Mouse and Chicken based on sequence homology. View All» Quality Assurance: Evaluated by western blot on untreated and Cerulenin treated MCF7 cell lysate.Western Blot Analysis: A 1:2,000 of this antibody detected Ras, H palmitoylated in untreated and Cerulenin treated MCF7 cell lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Antigen affinity purified rabbit serum in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8ºC from date of receipt. View All» UniProt Number: P01111 View All» Entrez Gene Number: NP_005334.1 View All» Gene Symbol:
  • ALPS4

  • HRAS1

  • N-ras

  • NRAS1

  • OTTHUMP00000013879
    View All» Alternate Names:
    • N-ras protein part 4

    • Transforming protein N-Ras

    • neuroblastoma RAS viral (v-ras) oncogene homolog

    • v-ras neuroblastoma RAS viral oncogene homolog
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a diseasecharacterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.ENZYME REGULATION: Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor. Note= Shuttles between the plasma membrane and the Golgi apparatus. PTM: Palmitoylated by the ZDHHC9-GOLGA7 complex. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi. INVOLVEMENT IN DISEASE: Defects in NRAS are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:607785]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia.Mutations which change AA 12, 13 or 61 activate the potential of Ras to transform cultured cells and are implicated in a variety of human tumors.SEQUENCE SIMILARITIES: Belongs to the small GTPase superfamily. Ras family. View All» Product Name: Anti-Ras, H Palmitoylated View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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