货号：09-104

品牌：Merck Millipore

规格：100Ug

目录价：￥3724.00

市场价格：￥3165.40

会员价格：￥2979.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-Raptor (Ser722) Antibody | 09-104 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Raptor phosphorylated at Ser722. View All» Molecular Weight: ~ 150 kDa View All» Epitope: Ser722 View All» Immunogen: KLH-conjugated linear peptide corresponding to human Raptor phosphorylated at and around Ser722. View All» Modifications: Phosphorylation View All» Background Information: Raptor is a subunit of mTORC1 which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino-acids. Within mTORC1, Raptor positively regulates mTORC1 activity and functions as a scaffold for recruiting mTORC1 substrates. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Bovine

• Canine

• Goat

• Chicken

• Horse
  View All» Species Reactivity Note: Reacts with human. Predicted to react with mouse, rat, cow, dog, goat, chicken and horse based on 100% sequence homology. View All» Control: Modified and non modified peptides of phosphorylated and non-phosphorylated Raptor protein View All» Quality Assurance: Evaluated by Dot Blot in modified and non modified peptides of phosphorylated and non-phosphorylated Raptor protein.Dot Blot Analysis: 1 µg/mL of this antibody detected Raptor in modified and non modified peptides of phosphorylated and non-phosphorylated Raptor protein. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in PBS with 0.09% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q8N122 View All» Entrez Gene Number: NP_065812 View All» Gene Symbol:
  • raptor

  • Raptor
    View All» Alternate Names:
    • P150 target of rapamycin (TOR)-scaffold protein

    • p150 target of rapamycin (TOR)-scaffold protein containing WD-repeats

    • regulatory associated protein of mTOR
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Dot Blot

      • Western Blotting
        View All» Entrez Gene Summary: This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Participates in the FRAP1 pathway and associates in a near stoichiometric ratio with FRAP1 to form a nutrient-sensitive complex (NSC). Plays a pivotal role as a scaffold protein in the FRAP1-signaling pathway and this interaction is essential for the catalyzed phosphorylation of EIF4EBP1. Has a positive role in nutrient-stimulated signaling to the downstream effector RPS6KB1. Under nutrient-deprived conditions, serves as a negative regulator of FRAP1 kinase activity. Regulation of the interaction with FRAP1 is a critical mechanism by which cells coordinate the rate of cell growth and maintenance of cell size with different environmental conditions.SIZE: 1335 amino acids; 149038 Da SUBUNIT: Binds directly 4EBP1 and RPS6KB1 independently of its association with FRAP1. Binds preferentially to poorly or non- phosphorylated form of EIF4EBP1, and this binding is critical to the ability of FRAP1 to catalyze phosphorylation. Complex with FRAP1 physically interacts under both leucine-rich and -poor conditions and therefore in at least two nutrient-determined states with different stability.TISSUE SPECIFICITY: Highly expressed in skeletal muscle, and in a lesser extent in brain, lung, small intestine, kidney and placenta.SIMILARITY: Contains 7 WD repeats. MISCELLANEOUS: Rapamycin destabilizes the interaction with FRAP1 regardless of nutrient availability, and its potency for dissociation is increased under nutrient-rich conditions. This action uncouples FRAP1 from its substrates, and inhibits FRAP1 signaling without altering its intrinsic catalytic activity. View All» Product Name: Anti-phospho-Raptor (Ser722) View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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