货号：09-094

品牌：Merck Millipore

规格：

目录价：￥3639.00

市场价格：￥3093.15

会员价格：￥2911.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-RFC1 Antibody | 09-094 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: RFC1 View All» Molecular Weight: 145 kDa View All» Immunogen: A synthetic peptide corresponding to amino acids 1125-1140 of human RFC1. View All» Isotype: IgG View All» Background Information: Replication factor C is a DNA-dependent ATPase that is required for eukaryotic DNA replication and repair. The protein acts as an activator of DNA polymerases, binds to the 3' end of primers, and promotes coordinated synthesis of both strands. It also may have a role in telomere stability. View All» Species Reactivity: Human View All» Application Notes: Suggested dilutions: Western Blot: 1:1000 View All» Quality Assurance: Routinely evaluated by immunoblot. View All» Purification Method: Immunoaffinity purified View All» Presentation: 100 μg of rabbit polyclonal IgG in 100μl of 1X PBS with 0.1% sodium azide. View All» Storage Conditions: 2 years at -20°C from date of shipment View All» UniProt Number: P35251 View All» Entrez Gene Number: NM_002913.3 View All» Gene Symbol:

• RFC1

• RECC1

• RFC140

• PO-GA

• A1

• MHCBFB

• MGC51786

• RFC
  View All» Alternate Names: Replication Factor C1, RF-C, MHC binding factor, beta, A1, MGC51786, MHCBFB, PO-GA, RECC1, RFC, RFC140 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene is the large subunit of replication factor C, which is a five subunit DNA polymerase accessory protein. Replication factor C is a DNA-dependent ATPase that is required for eukaryotic DNA replication and repair. The protein acts as an activator of DNA polymerases, binds to the 3' end of primers, and promotes coordinated synthesis of both strands. It also may have a role in telomere stability. View All» UniProt Summary: FUNCTION: SwissProt: P35251 # Interacts with C-terminus of PCNA. 5' phosphate residue is required for binding of the N-terminal DNA-binding domain to duplex DNA, suggesting a role in recognition of non-primer template DNA structures during replication and/or repair.SIZE: 1148 amino acids; 128255 Da SUBUNIT: Heteropentamer of subunits of 140/145, 40, 38, 37, and 36.5 kDa that forms a complex with PCNA in the presence of ATP.SUBCELLULAR LOCATION: Nucleus.TISSUE SPECIFICITY: Wide tissue distribution. Undetectable in placental tissue.PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.SIMILARITY: SwissProt: P35251 ## Belongs to the activator 1 140 kDa subunit family. & Contains 1 BRCT domain. View All» Brand Family: Upstate View All» Product Name: Anti-RFC1 Antibody | 09-094 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
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