货号：09-090

品牌：Merck Millipore

规格：

目录价：￥4376.00

市场价格：￥3719.60

会员价格：￥3500.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-CHD9 Antibody | 09-090 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes CHD9. View All» Molecular Weight: ~ 326 kDa View All» Epitope: Linear peptide correponding to internal region between amino acids 2580-2610 View All» Immunogen: KLH-conjugated linear peptide corresponding to human CHD9. View All» Background Information: CHD9 is a member of the chromodomain-helicase-DNA-binding family of proteins. Consistent with other members of this family this protein functions as an ATP-dependent chromatin remodeling protein that interacts with nucleosomes and plays a role in chromatin remodeling to modulate transcription. CHD9 has been shown to possess DNA-dependent ATPase activity and to associate with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. The CHD9 protein is a member of the SNF2/RAD54 helicase family and contains two chromodomains (chromatin organization modifiers), single helicase/ATPase domain, as well as a helicase C-terminal domain.This protein is found in both the cytoplasm and nucleus and can be phosphorylated on serine and tyrosine residues. This protein is widely expressed in a variety of tissues at at low levels. In bone marrow, expression is restricted to osteoprogenitor cells adjacent to mature osteoblasts. CHD9 has been shown to interact with PPARA to function as a transcriptional coactivator. This protein also possibly interacts with other nuclear receptors such as with ESR1 (Estrogen Receptor-alpha) and NR1I3 (constitutive androstane receptor/CAR). View All» Species Reactivity:

• Human

• Rat

• Mouse

• Chimpanzee

• Horse
  View All» Species Reactivity Note: Demonstrated to react with human. Predicted to react with rat, mouse, chimpanzee, and equine based on 100% sequence homology. View All» Application Notes: Imunocytochemistry Analysis: 1:500 dilution from a previous lot detected CHD9 in HeLa and A431 cells. View All» Control: HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot in HeLa cell lysate.Western Blot Analysis: 0.1 µg/ml of this antibody detected CHD9 on 10 µg of HeLa cell lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q3L8U1 View All» Entrez Gene Number: NP_079410 View All» Gene Symbol:
  • CHD9

  • AD013

  • BC022889

  • CHD-9

  • CReMM

  • KISH2

  • PRIC320

  • proteinx0008
    View All» Alternate Names:
    • ATP-dependent helicase CHD9

    • Chromatin-related mesenchymal modulator

    • Chromatin-remodeling factor CHROM1

    • Kismet homolog 2

    • PPAR-alpha-interacting complex protein 320 kDa

    • PPAR{gamma}-interacting cofactor 320 kDa

    • Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein

    • chromatin remodeling factor CHROM1

    • chromodomain helicase DNA binding protein 9

    • ciprofibrate bound protein p240
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry
        View All» UniProt Summary: FUNCTION: Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Proposed to be a ATP-dependent chromatin remodeling protein. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis By similarity.SUBUNIT STRUCTURE: Interacts with PPARA. Probably interacts with ESR1 and NR1I3. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. TISSUE SPECIFICTY: Widely expressed at low levels. In bone marrow, expression is restricted to osteoprogenitor cells adjacent to mature osteoblasts. PTM: Phosphorylated on serine and tyrosine residues. SEQUENCE SIMILARITIES: Belongs to the SNF2/RAD54 helicase family.Contains 2 chromo domains.Contains 1 helicase ATP-binding domain.Contains 1 helicase C-terminal domain.SEQUENCE CAUTION: The sequence AAF24170.1 differs from that shown. Reason: Erroneous translation. Wrong choice of frame. View All» Product Name: Anti-CHD9 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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