货号：09-029

品牌：Merck Millipore

规格：

目录价：￥3767.00

市场价格：￥3201.95

会员价格：￥3013.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-CBX4 Antibody | 09-029 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody detects the postchromo domain of CBX4. View All» Molecular Weight: ~65 kDa View All» Epitope: Postchromo Domain View All» Immunogen: GST-tagged recombinant protein corresponding to the postchromo domain of CBX4. View All» Background Information: The family of Heterochromatin Proteins ("Chromobox Homolog", CBX) are highly conserved adapter molecules, which have important functions in the cell nucleus. These functions include gene repression by heterochromatin formation, transcriptional activation, regulation of binding of cohesion complexes to centromere, sequesteration of genes to nuclear periphery, transcriptional arrest, maintenance of heterochromatin integrity, gene repression at single nucleosome level, and gene repression by heterochromatization of euchromatin. View All» Species Reactivity:

• Mouse

• Human
  View All» Species Reactivity Note: Mouse and human View All» Application Notes: SNAP I.D. (western blotting technique): A previous lot of this antibody worked successfully using the SNAP I.D. western blotting device and technique. View All» Control: NIH/3T3 nuclear extract, HeLa cell nuclear extract View All» Quality Assurance: Evaluated by western blot on HeLa nuclear extract.Western Blot Analysis: 0.5-2 µg/mL of this antibody detected CBX4 in HeLa nuclear extract. View All» Purification Method: Protein A purfied View All» Presentation: Purified rabbit polyclonal in buffer containing PBS and 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8ºC from date of receipt. View All» UniProt Number: O00257 View All» Entrez Gene Number: NM_007625 View All» Gene Symbol:
  • NBP16

  • PC2

  • Pc2

  • hPC2

  • hPc2
    View All» Alternate Names:
    • Chromobox protein homolog 4

    • NS5ATP1-binding protein 16

    • Polycomb 2 homolog

    • chromobox homolog 4

    • chromobox homolog 4 (Drosophila Pc class)

    • chromobox homolog 4 (Pc class homolog, Drosophila)
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTIONS: E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. PATHWAY: Protein modification; protein sumoylation.SUBUNIT STRUCTURE: Interacts with histone H3-K9Me3 By similarity. Component of chromatin-associated class II PcG repressive complex 1 (PRC1/hPRC-H) at least composed of PCGF2/RNF110, BMI1/PCGF4, CBX2/M33, CBX4/PC2, CBX8/PC3, PHC1, PHC2, PHC3, SCMH1, RING1 and RNF2/RING2. Interacts with SUV39H1 and HIPK2.SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Ubiquitous.PTM: Phosphorylated on Thr-495 by HIPK2 upon DNA damage; which enhances E3 SUMO-protein ligase activity and promotes sumoylation on Lys-492. SEQUENCE SIMILARITIES: Contains 1 chromo domain. View All» Product Name: Anti-CBX4 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
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