货号：08-146

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: ISG15 Protein View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 100 µg View All» Product Overview: ISG15 protein is a recombinant protein produced in E. coli corresponding to the human sequence encompassing an N-terminal His6-tag within a leader sequence. ISG15 was originally identified as an interferon stimulated gene (ISG) whose expression is highly induced upon interferon treatment. ISG15 contains two ubiquitin homology domains in tandem and shows ~30% identity to ubiquitin. ISG15 is conserved in dispersed regions and homology among the five identified mammalian proteins is around 47%. It is synthesized as a 17 kDa precursor form and processed to 15 kDa protein by a specific protease in order to expose di-glycine residues at the carboxyl terminus, which is critical for subsequent conjugation to target proteins. View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: G1P2 is a ubiquitin-like protein that becomes conjugated to many cellular proteins upon activation by interferon-alpha (IFNA; MIM 147660) and -beta (IFNB; MIM 147640) (Zhao et al., 2005 [PubMed 16009940]).[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: P05161 # In response to IFN-tau secreted by the conceptus, may ligate to and regulate proteins involved in the release of prostaglandin F2-alpha (PGF), and thus prevent lysis of the corpus luteum and maintain the pregnancy (By similarity).SIZE: 165 amino acids; 17888 Da SUBUNIT: Interacts with, and is conjugated to its targets by the UBE1L (E1 enzyme) and UBE2E2 (E2 enzyme) (Probable). Interaction with influenza B NS1 protein inhibits this conjugation.SUBCELLULAR LOCATION: Cytoplasm. Secreted. Note=UCRP conjugates seem to be noncovalently associated with the intermediate filaments and distributed in a punctate pattern. Also secreted.TISSUE SPECIFICITY: Detected in lymphoid cells, striated and smooth muscle, several epithelia and neurons.SIMILARITY: SwissProt: P05161 ## Contains 2 ubiquitin-like domains. View All» Species: Human View All» Molecular Weight: 22 kDa View All» Brand Family: Upstate View All» Presentation: 100 µg of concentration 1.0 mg/mL in 20mM HEPES, pH8.0, 50mM NaCl, 1mM DTT. View All» Storage Conditions: Stable for 1 year at -80°C from date of shipment for up to 12 months. Avoid multiple freeze/thaw cycles. After initial defrost, aliquot into individual tubes and refreeze at -80ºC. View All» Gene Symbol:

• ISG15

• UCRP

• IFI15

• G1P2
  View All» Product Name: ISG15 Protein View All» UniProt Number: P05161 View All» Entrez Gene Number: NM_005101.2 View All» Purity: ≥95% View All»
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