货号：08-145

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: NEDD8 Protein View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 100 µg View All» Product Overview: NEDD8 protein is a recombinant protein produced in E. coli corresponding to the human sequence encompassing an N-terminal His6-tag within a leader sequence. NEDD8, ubiquitin-like molecule, shares ~60% identity with ubiquitin at the amino acid level that can be covalently conjugated (neddylation) to a limited number of cellular proteins in a fashion similar to that of ubiquitin. The C-terminus of pro-NEDD8 is efficiently processed to expose glycine76 in the mature form. This processing is required for conjugation to target proteins via a range of specific activating and conjugating enzymes. View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» UniProt Summary: FUNCTION: SwissProt: Q15843 # Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C- APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.SIZE: 81 amino acids; 9072 Da SUBUNIT: Directly interacts with NUB1 and AHR. Covalently attached to cullins and p53.SUBCELLULAR LOCATION: Nucleus. Note=Mainly nuclear.TISSUE SPECIFICITY: Highly expressed in heart, skeletal muscle, spleen, thymus, prostate, testis, ovary, colon and leukocytes.PTM: Cleavage of precursor form by UCHL3 or SENP8 is necessary for function.SIMILARITY: SwissProt: Q15843 ## Belongs to the ubiquitin family. View All» Species: Human View All» Molecular Weight: 14 kDa View All» Brand Family: Upstate View All» Presentation: 100 µg of concentration 0.5 mg/mL in 20mM HEPES, pH8.0, 50mM NaCl, 1mM DTT, 10% glycerol. View All» Storage Conditions: Stable for 1 year at -80°C from date of shipment for up to 12 months. Avoid multiple freeze/thaw cycles. After initial defrost, aliquot into individual tubes and refreeze at -80ºC. View All» Gene Symbol:

• NEDD8

• MGC125897

• Neddylin

• Nedd-8

• MGC125896

• FLJ43224

• MGC104393
  View All» Product Name: NEDD8 Protein View All» Concentration: 0.5 mg/mL View All» UniProt Number: Q15843 View All» Entrez Gene Number: NM_006156.2 View All» Purity: ≥95% View All»
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