货号：07-955

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Hexim 1 Antibody | 07-955 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Hexim1 at the N-terminus. View All» Molecular Weight: 53 kDa View All» Epitope: N-terminus View All» Immunogen: KLH-conjugated linear peptide corresponding to human Hexim 1 at and around the N-terminus. View All» Background Information: Hexim1 is a transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. Hexim1 works in cooperation with 7SK snRNA to sequester P-TEFb in a large inactive 7SK snRNP complex, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. The 7SK snRNP complex is composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), Hexim1, Hexim2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. Hexim1 also interacts with the N-CoR complex through NCOR1, ESR1, NR3C1, and may interact with NF-kappa-B through REL A. Hexim1 is located in the nucleus where it can bind with alpha-importin, and can also be found in the cytoplasm. Hexim1 is up-regulated by HMBA (hexamethylene bisacetamide) at the protein level and down-regulated by estrogen. View All» Species Reactivity:

• Human

• Chimpanzee
  View All» Species Reactivity Note: Demonstrated to react with human. Predicted to react with chimpanzee and Rhesus monkey based on 100% sequence homology. View All» Application Notes: Western Blot (SNAP ID) Analysis: 4 µg/ml from a previous lot detected Hexim 1 on 10 µg of HeLa cell lysate.Immunoprecipitation Analysis: A representative lot of this antibody was used by an independent laboratory for IP. View All» Control: HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot in HeLa cell lysate.Western Blot Analysis: 0.1 µg/ml of this antibody detected Hexim 1 on 10 µg of HeLa cell lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: O94992 View All» Entrez Gene Number: NP-006451 View All» Gene Symbol:
  • CLP-1

  • CLP1

  • EDG1

  • HIS1

  • HMBA-inducible

  • MAQ1

  • Hexim1
    View All» Alternate Names:
    • Cardiac lineage protein 1

    • Estrogen down-regulated gene 1 protein

    • Hexamethylene bis-acetamide-inducible protein 1

    • Menage a quatre protein 1

    • hexamethylene bis-acetamide inducible 1

    • hexamethylene bisacetamide-inducible protein

    • hexamethylene-bis-acetamide-inducible transcript 1

    • hexamthylene bis-acetamide inducible 1

    • menage a quatre 1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunoprecipitation
        View All» Entrez Gene Summary: Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns. View All» UniProt Summary: FUNCTION: Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity. SUBUNIT STRUCTURE: Homo-oligomer and hetero-oligomer with HEXIM2; probably dimeric. Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. Interacts with the N-CoR complex through NCOR1. Interacts with ESR1 and NR3C1. May interact with NF-kappa-B through RELA. SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note: Binds alpha-importin and is mostly nuclear. TISSUE SPECIFICITY: Ubiquitously expressed with higher expression in placenta. HEXIM1 and HEXIM2 are differentially expressed. Expressed in endocrine tissues. INDUCTION: Up-regulated by HMBA (hexamethylene bisacetamide) (at protein level). Down-regulated by estrogen. DOMAIN: The coiled-coil domain mediates oligomerization.MISCELLANEOUS: Inhibits Tat activity which is required for HIV-1 transcription.SEQUENCE SIMILARITIES: Belongs to the HEXIM family. View All» Product Name: Anti-Hexim 1 Antibody (07-955) View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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