R&D Systems代理4969-BA-050 Recombinant Human BAI1 Protein, CF (50 UG)-试剂-金山科研平台

R&D Systems代理4969-BA-050 Recombinant Human BAI1 Protein, CF (50 UG)

2025-06-28

货号：4969-BA-050

品牌：R&D Systems

规格：50ug

目录价：￥4490.00

市场价格：￥3592.00

会员价格：￥3592.00

到货时间：3~4周

金山科研平台，产品价格货期咨询微信：jinshanbio Source:Chinese Hamster Ovary cell line, CHO-derived, Ala31-Thr879, with a C-terminal 6-His tag Accession #:O14514 N-terminal Sequence Analysis:Ala31 Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:93.6 kDa SDS-PAGE:105-115 kDa, reducing conditions Activity:Measured by the ability of the immobilized protein to support the adhesion of BCE C/D‑1b bovine corneal endothelial cells.

When 4 x 10⁴ cells per well are added to rhBAI1 coated plates (0.5 µg/mL, 100µL/well), approximately 40%-70% will adhere after 1 hour at 37°C.

Optimal dilutions should be determined by each laboratory for each application.

Formulation:Lyophilized froma 0.2 µm filtered solution in PBS.See Certificate of Analysis for details. Molecule Information: BAI1 Long Name: Brain-specific Angiogenesis Inhibitor 1 Entrez Gene IDs: 575 (Human); 107831 (Mouse); 362931 (Rat) Background: BAI1 Brain Angiogenesis Inhibitor 1 (BAI1) is a 170 kDa 7-transmembrane domain G protein-coupled receptor (GPCR) that has a large N-terminal extracellular region with an RGD motif, five thrombospondin type I repeats, and a juxtamembrane GPS (GPCR proteolytic cleavage site). Within the extracellular domain (ECD) up to the GPS (amino acids 31-879), mature human BAI1 shares 94% amino acid sequence identity with mouse and rat BAI1. BAI1 is preferentially expressed on brain neurons but also is found on astrocytes and macrophages and in the pancreas, stomach, and colon. BAI1 can be cleaved within the GPS to release a 120 kDa fragment termed Vasculostatin which corresponds to nearly the entire N-terminal ECD. Generation of additional soluble fragments suggests the cleavage of BAI1 at multiple sites. BAI1 fragments interact with Integrin alpha V beta 5 or CD36 on microvascular endothelial cells to inhibit cell proliferation and migration. Overexpression of BAI1 in glioblastoma or pancreatic adenocarcinoma cells inhibits their tumorigenicity and the development of tumor-associated neovascularization. Fragments of the ECD, including Vasculostatin, also suppress in vivo angiogenesis and tumor growth. BAI1 is down-regulated in glioblastoma, carcinomas of the pancreas, colon, and stomach and also in experimental ischemia. Its expression is inversely correlated with tumor vascularity in colorectal and pulmonary carcinomas. On macrophages and astrocytes, BAI1 mediates the phagocytosis of apoptotic cells through recognition of cell surface phosphatidylserine.

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