金山科研平台，产品价格货期咨询微信：jinshanbio Source:Mouse myeloma cell line, NS0-derived Accession #:Q02955 N-terminal Sequence Analysis:Leu20 Structure:Disulfide-linked homodimer Purity:>90%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:64.3 kDa (monomer) SDS-PAGE:85-100 kDa, reducing conditions Activity:Measured by its ability to inhibit IL-1 alpha -dependent proliferation in D10.G4.1 mouse helper T cells. Symons, J.A. etal. (1987) in Lymphokines and Interferons, a Practical Approach. Clemens, M.J. etal. (eds): IRL Press. 272.Approximately 5-20µg/mL of rrIL-1 RI/Fc will inhibit 50% of the biological response due to 15pg/mL of rrIL-1a. Formulation:Lyophilized from a 0.2 µm filtered solution in PBS.See Certificate of Analysis for details. Molecule Information: IL-1 RI Long Name: Interleukin 1 Receptor I Aliases: CD121a; IL1R1 Entrez Gene IDs: 3554 (Human); 16177 (Mouse) Background: IL-1 RI The Interleukin 1 receptor family comprises at least nine members. All family members possess three immunoglobulin (Ig)-like domains in their extracellular region. Most members also have an intracellular TIR (Toll-like receptor/IL-1 receptor) signaling domain that is also conserved in the Toll-like receptor family. A subtype of the IL-1 R family, SIGIRR (single Ig domain-containing IL-1 R-related molecule) differs from the other nine members by having only one Ig domain.

IL-1 R1 is a type I transmembrane glycoprotein that functions as the ligand binding subunit in the IL-1 receptor complex. It associates with a signaling component, IL-1 R3 (IL-1 receptor accessory protein) to form a functional receptor complex for IL-1 alpha and IL-1 beta.