货号：07-869

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-PKA Antibody, Regulatory subunit IIβ (Ser114) | 07-869 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes phospho-PKA Reg IIβ (Ser114). View All» Immunogen: Peptide corresponding to amino acid region encompassing the human, mouse, rat, cow and rabbit phospho-PKA Reg IIβ (Ser114). View All» Modifications: Phosphorylation View All» Isotype: IgG View All» Species Reactivity: Mouse View All» Species Reactivity Note: Human, rat, rabbit, and bovine expected to react based on sequence similarity, but have not been tested. View All» Quality Assurance: Routinely evaluated by immunoblot. View All» Purification Method: Immunoaffinity purified View All» Presentation: 100 μL of affinity purified rabbit polyclonal IgG in 50% storage buffer (PBS (without Mg²⁺ and Ca²⁺), pH 7.3 containing 1.0 mg/mL BSA (IgG, protease free) and 0.05% sodium azide) and 50% glycerol. View All» Storage Conditions: Stable for 2 years at -20°C from date of shipment. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerolcontaining solutions to become frozen during storage. View All» UniProt Number: P31323 View All» Entrez Gene Number: NM_002736.2 View All» Gene Symbol:

• PRKAR2B

• RII-BETA

• H_RG363E19.2

• WUGSC:H_RG363E19.2

• PRKAR2
  View All» Alternate Names: PRKAR2B, PRKAR2, RII-BETA, cAMP dependent protein kinase View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. View All» UniProt Summary: FUNCTION: SwissProt: P31323 # Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.SIZE: 418 amino acids; 46346 Da SUBUNIT: The inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules.TISSUE SPECIFICITY: Four types of regulatory chains are found: I- alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.PTM: Phosphorylated by the activated catalytic chain.SIMILARITY: SwissProt: P31323 ## Belongs to the cAMP-dependent kinase regulatory chain family. & Contains 2 cyclic nucleotide-binding domains. View All» Brand Family: Upstate View All» Product Name: Anti-phospho-PKA Antibody, Regulatory subunit IIβ (Ser114) | 07-869 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
  © 金山科研平台是专业的授权总代理区域代理经销平台。
  © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
  © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
  © 本文地址：https://16ao.com/thread-136438.htm
  © Merck Millipore代理07-869 anti-phospho-PKA Reg IIb (Ser114);已停产，产品报价联系微信jinshanbio