货号：07-857

品牌：Merck Millipore

规格：

目录价：￥3662.00

市场价格：￥3112.70

会员价格：￥2929.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-MKK4 (Ser257/Thr261) Antibody | 07-857 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes phospho-MKK4 (MEK4) (Ser257/Thr261) View All» Molecular Weight: 42 kDa View All» Immunogen: Peptide corresponding to amino acid region encompassing the human, mouse, and frog phospho-MEK4 (MEK4) (Ser257/Thr261). View All» Modifications: Phosphorylation View All» Isotype: IgG View All» Species Reactivity: Human View All» Species Reactivity Note: Predicted to cross-react with Mouse based on complete sequence homology. View All» Quality Assurance: Routinely evaluated by immunoblot. View All» Purification Method: Immunoaffinity purified View All» Presentation: 100 μL of affinity purified rabbit polyclonal IgG in 50% storage buffer (PBS (without Mg²⁺ & Ca²⁺), pH 7.3 containing 1.0 mg/mL BSA (IgG, protease free) and 0.05% sodium azide). View All» Storage Conditions: Stable for 2 years at -80°C from date of shipment. View All» UniProt Number: P45985 View All» Entrez Gene Number: NM_003010.2 View All» Gene Symbol:

• MAP2K4

• MKK4

• JNKK

• MEK4

• MAPKK4

• JNKK1

• SEK1

• SERK1

• PRKMK4
  View All» Alternate Names: MAP2K4, JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SEK1, SERK1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver. View All» UniProt Summary: FUNCTION: SwissProt: P45985 # Dual specificity kinase that activates the JUN kinases MAPK8 (JNK1) and MAPK9 (JNK2) as well as MAPK14 (p38) but not MAPK1 (ERK2) or MAPK3 (ERK1).SIZE: 399 amino acids; 44288 Da SUBUNIT: Interacts with SPAG9 (By similarity).TISSUE SPECIFICITY: Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.PTM: Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases (By similarity).SIMILARITY: SwissProt: P45985 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. & Contains 1 protein kinase domain. View All» Brand Family: Upstate View All» Product Name: Anti-phospho-MKK4 (Ser257/Thr261) Antibody | 07-857 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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