金山科研平台，产品价格货期咨询微信：jinshanbio Source:Chinese Hamster Ovary cell line, CHO-derived Accession #:NP_002183 ( beta A) & NP_005529 ( beta C) N-terminal Sequence Analysis:Gly311 ( beta A subunit) & Gly237 ( beta C subunit) Structure:Disulfide-linked heterodimer Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:12.9 kDa ( beta A subunit), 12.5 kDa ( beta C subunit) SDS-PAGE:23 kDa, reducing conditions Activity:Measured by its binding ability in a functional ELISA.In a 100 µL reaction mixture containing rhActivinAC at 2 nM and rhActivinRIIB/Fc Chimera dilutions at 0.02 - 41 nM, the concentration of rhActivin RIIB/Fc Chimera (R&D Systems, Catalog# 339-RBB) that produces 50%of the optimal binding response is found to be approximately 0.8 - 4 nM. Molecule Information: Activin AC Background: Activins

Activins, members of the TGF-beta superfamily, are disulfide-linked dimeric proteins originally purified from gonadal fluids as proteins that stimulated pituitary follicle stimulating hormone (FSH) release. Activin proteins have a wide range of biological activities, including mesoderm induction, neural cell differentiation, bone remodeling, hematopoiesis and roles in reproductive physiology. Activin isoforms and other members of the TGF-beta superfamily exert their biological effects by binding to heteromeric complexes of a type I and a type II serine-threonine kinase receptor, both of which are essential for signal transduction.

Activins are homodimers or heterodimers of the various beta subunit isoforms, while inhibins are heterodimers of a unique alpha subunit and one of the various beta subunits. Five beta subunits (mammalian beta A, beta B, beta C, beta E and Xenopus beta D) have been cloned to date. The activin/inhibin nomenclature reflects the subunit composition of the proteins: Activin A (beta A - beta A), Activin B (beta B - beta B), Activin AB (beta A - beta B), Inhibin A (alpha - beta A) and Inhibin B (alpha - beta B).