货号：07-813

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-Raf-1 (Ser621) Antibody | 07-813 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes phosphorylated Raf-1 (Ser621). May cross react with A-Raf and B-Raf in various cell types (determined by sequence homology). View All» Molecular Weight: 74 kDa View All» Immunogen: Peptide corresponding to amino acid region encompassing the human, mouse, and rat phospho-Raf-1 (Ser621) View All» Modifications: Phosphorylation View All» Isotype: IgG View All» Species Reactivity: Human View All» Species Reactivity Note: Predicted to cross-react with mouse and rat based on sequence similarity (100%), but have not been tested. View All» Application Notes: Immunoblot Analysis: A 1:1,000 dilution of this lot detected phospho-Raf (Ser621) in RIPA lysate of HEK293 c-Raf transfected cell that have been EGF treated. View All» Quality Assurance: Routinely evaluated by immunoblot. View All» Purification Method: Affinity Purfied View All» Presentation: 100 μL of affinity purified rabbit polyclonal IgG in 50% storage buffer (PBS (without Mg²⁺ and Ca²⁺), pH 7.3 containing 1.0 mg/mL BSA (IgG, protease free) and 0.05% sodium azide) and 50% glycerol. View All» Storage Conditions: Stable for 2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage. View All» UniProt Number: P04049 View All» Entrez Gene Number: NM_002880.2 View All» Gene Symbol:

• RAF1

• C-RAF

• cRaf

• Raf-1

• c-Raf

• CRAF

• RAF
  View All» Alternate Names: CRAF; Raf-1; c-Raf View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Raf-1 is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. [Contributed text] View All» UniProt Summary: FUNCTION: SwissProt: P04049 # Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. Part of the Ras-dependent signaling pathway from receptors to the nucleus. Protects cells from apoptosis mediated by STK3.COFACTOR: Binds 2 zinc ions per subunit.SIZE: 648 amino acids; 73052 Da SUBUNIT: Interacts with Ras proteins. The interaction with Ras is antagonized by RIN1. Weakly interacts with RIT1 (By similarity). Interacts with STK3, which inhibits its pro-apoptotic activity.PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.SIMILARITY:SwissProt: P04049 ## Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. & Contains 1 phorbol-ester/DAG-type zinc finger. & Contains 1 protein kinase domain. & Contains 1 RBD (Ras-binding) domain. View All» Brand Family: Upstate View All» Product Name: Anti-phospho-Raf-1 (Ser621) Antibody | 07-813 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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