货号：07-728

品牌：Merck Millipore

规格：100UL

目录价：￥5053.00

市场价格：￥4295.05

会员价格：￥4042.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-HRI Antibody | 07-728 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: HRI View All» Molecular Weight: 72kDa View All» Immunogen: 6His-tagged fusion protein corres-ponding to residues 1-138 of mouse heme-regulated inhibitor (HRI) View All» Isotype: IgG View All» Species Reactivity:

• Human

• Mouse

• Rabbit
  View All» Quality Assurance: Routinely evaluated by immunoblot on lysates from mouse reticulocytes. View All» Purification Method: Serum View All» Storage Conditions: 2 years at -20°C from date of shipment View All» UniProt Number: Q9BQI3 View All» Entrez Gene Number: NM_014413.2 View All» Gene Symbol:
  • EIF2AK1

  • KIAA1369

  • HCR

  • HRI
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunoprecipitation

    • Western Blotting
      View All» Entrez Gene Summary: The HRI gene is localized to 7p22 where its 3' end slightly overlaps the 3' end of the gene JTV1. The two genes are transcribed from opposite strands. Studies in rat and rabbit suggest that the HRI gene product phosphorylates the alpha subunit of eukaryotic initiation factor 2. Its kinase activity is induced by low levels of heme and inhibited by the presence of heme. View All» UniProt Summary: FUNCTION: SwissProt: Q9BQI3 # Mediates down-regulation of protein synthesis in response to various stress conditions by the phosphorylation of EIF2S1 at 'Ser-48' and 'Ser-51'. Protein synthesis is inhibited at the level of initiation (By similarity).SIZE: 630 amino acids; 71106 Da SUBUNIT: Synthesized in an inactive form that binds to the N- terminal domain of CDC37. Has to be associated with a multiprotein complex containing Hsp90, CDC37 and PPP5C for maturation and activation by autophosphorylation. The phosphatase PPP5C modulates this activation. Homodimer; non-covalently bound in the absence of hemin. Converted to an inactive disulfide linked homodimer in the presence of hemin (By similarity).TISSUE SPECIFICITY: Detected in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, kidney, spleen, muscle and stomach.PTM: Activated by autophosphorylation; phosphorylated predominantly on serine and threonine residues, but also on tyrosine residues (By similarity).SIMILARITY: SwissProt: Q9BQI3 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. & Contains 2 HRM (heme regulatory motif) repeats. & Contains 1 protein kinase domain. MISCELLANEOUS: Can bind 2 molecules of heme per polypeptide chain (By similarity)." View All» Brand Family: Upstate View All» Product Name: Anti-HRI Antibody | 07-728 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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