货号：07-710

品牌：Merck Millipore

规格：100UL

目录价：￥6127.00

市场价格：￥5207.95

会员价格：￥4901.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-SMC2/hCAP-E Antibody | 07-710 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Product Overview: SMC2 and SMC4 from the active ATPase subunit of Condensin I and Condensin II complexes that regulate chromosome compaction. View All» Specificity: SMC2/hCAP-E View All» Molecular Weight: 137kDa View All» Immunogen: KLH-conjugated, synthetic peptide corresponding to amino acids 1184-1197 (C-KSKAKPPKGAHVEV) of human SMC2/hCAP-E (Structural Maintenance of Chromosome 2/ Chromosome-Associated Protein E) with an N-terminal cysteine added for conjugation purposes. View All» Species Reactivity: Human View All» Quality Assurance: Routinely evaluated by immunoblot. View All» Purification Method: Serum View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: O95347 View All» Entrez Gene Number:

• NM_001042550.1

• NM_001042551.1

• NM_006444.2
  View All» Gene Symbol:
  • SMC2

  • SMC2L1

  • hCAP-E

  • FLJ10093

  • CAPE

  • CAP-E
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: SwissProt: O95347 # Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.SIZE: 1197 amino acids; 135781 Da SUBUNIT: Forms an heterodimer with SMC4. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRRN1/CAPH, CNAP1/CAPD2 and CAPG.SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.DOMAIN: SwissProt: O95347 The hinge domain, which separates the large intramolecular coiled coil regions, allows the heterodimerization with SMC4, forming a V-shaped heterodimer (By similarity).SIMILARITY: Belongs to the SMC family. SMC2 subfamily. View All» Brand Family: Upstate View All» Product Name: Anti-SMC2/hCAP-E Antibody | 07-710 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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