货号：07-701

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-hCAP-D2/CNAP1 Antibody | 07-701 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Product Overview: hCAP-D2 / CNAP1 (aka chromosome condensation-related SMC-associated protein 1) is a member of the Condensin I protein complex involved in chromosome compaction. The C-terminal region defines a novel histone-binding domain that is responsible for targeting CNAP1, and possibly Condensin, to mitotic chromosomes. View All» Specificity: Human View All» Molecular Weight: 160 kDal View All» Immunogen: KLH-conjugated, synthetic peptide (C-TTPILRASARRHRS) corresponding to amino acids 1388-1401 of human hCAP-D2/CNAP1 (Chromosome-associated protein D2/chromosome condensation-related SMC-associated protein 1) with a N-terminal cysteine added for conjugation purposes. View All» Species Reactivity: Human View All» Quality Assurance: Routinely evaluated by immunoblot. View All» Storage Conditions: 2 years at -20°C from date of shipment View All» UniProt Number: Q15021 View All» Entrez Gene Number: NM_014865.2 View All» Gene Symbol:

• NCAPD2

• CAP-D2

• hCAP-D2

• CNAP1

• CAPD2

• KIAA0159
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: SwissProt: Q15021 # Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain.SIZE: 1401 amino acids; 157169 Da SUBUNIT: Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: NCAPH/BRRN1, NCAPD2/CAPD2 and NCAPG. Interacts with histones H1 and H3.SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.DOMAIN: SwissProt: Q15021 The C-terminal domain interacts with histones H1 and H3, and may be responsible for condensin complex targeting to mitotic chromosomes. This domain is independent from the bipartite nuclear localization signal, although they are contained within the same region.PTM: Phosphorylated by CDC2. Its phosphorylation, as well as that of NCAPH and NCAPG subunits, activates the condensin complex and is required for chromosome condensation (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.SIMILARITY: Belongs to the CND1 (condensin subunit 1) family. View All» Brand Family: Upstate View All» Product Name: Anti-hCAP-D2/CNAP1 Antibody | 07-701 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
  © 金山科研平台是专业的授权总代理区域代理经销平台。
  © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
  © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
  © 本文地址：https://16ao.com/thread-136208.htm
  © Merck Millipore代理07-701 Anti-hCAP-D2/CNAP1;已停产，产品报价联系微信jinshanbio