货号：07-674

品牌：Merck Millipore

规格：200UL

目录价：￥6127.00

市场价格：￥5207.95

会员价格：￥4901.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Na+K+ ATPase α-2 Antibody | 07-674 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Na⁺/K⁺ ATPase α-2 View All» Molecular Weight: Mr 105kDa View All» Immunogen: KLH-conjugated, synthetic peptide (CKAGQENISVSKRDT) corresponding to amino acids 432-445 of human Na⁺K⁺ ATPase α-2, with an N-terminal cysteine added for conjugation purposes. View All» Isotype: IgG View All» Species Reactivity: Rat View All» Species Reactivity Note: Predicted to crossreact with human, mouse, dog and monkey based on sequence homology. View All» Quality Assurance: Routinely evaluated by immunoblot with rat brain microsomal preparation (catalog# 12-144) View All» Purification Method: Antiserum View All» Storage Conditions: Stable for 2 years at -20°C from date of shipment View All» UniProt Number: P50993 View All» Entrez Gene Number: NM_000702.2 View All» Gene Symbol:

• ATP1A2

• FHM2

• MGC59864

• KIAA0778

• MHP2

• Na

• +K
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 2 subunit. View All» UniProt Summary: FUNCTION: SwissProt: P50993 # This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients.SIZE: 1020 amino acids; 112265 Da SUBUNIT: Composed of three subunits: alpha (catalytic), beta and gamma.SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.DISEASE: SwissProt: P50993 # Defects in ATP1A2 are the cause of familial hemiplegic migraine 2 (FHM2) [MIM:602481]. Familial hemiplegic migraine is a rare, severe, autosomal dominant subtype of migraine characterized by aura and some hemiparesis. & Defects in ATP1A2 are a cause of alternating hemiplegia of childhood (AHC) [MIM:104290]. AHC is typically distinguished from familial hemiplegic migraine by infantile onset of the symptoms and high prevalence of associated neurological deficits that become increasingly obvious with age.SIMILARITY: SwissProt: P50993 ## Belongs to the cation transport ATPase (P-type) family. Type IIC subfamily. View All» Brand Family: Upstate View All» Product Name: Anti-Na+K+ ATPase α-2 Antibody | 07-674 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µL View All» Format: Serum View All» Host: Rabbit View All»
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