货号：07-651

品牌：Merck Millipore

规格：100Ug

目录价：￥4967.00

市场价格：￥4221.95

会员价格：￥3973.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-SKAP-55 Antibody | 07-651 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: SKAP-55 View All» Molecular Weight: Mr 50-55kDa View All» Immunogen: GST fusion protein corresponding to residues 2-105 of human Src kinase-associated phosphoprotein of 55kDa (SKAP-55) View All» Isotype: IgG View All» Species Reactivity: Human View All» Quality Assurance: routinely evaluated by immunoblot on modified RIPA lysates from Jurkat cells View All» Purification Method: Protein G purfied View All» Presentation: PBS with 0.05% sodium azide and 30% gycerol View All» Storage Conditions: 2 years at -20°C from date of shipment View All» UniProt Number: Q86WV1 View All» Entrez Gene Number:

• NM_001075099.1

• NM_003726.3
  View All» Gene Symbol:
  • SKAP1

  • SCAP1

  • SKAP55

  • SKAP-55

  • pp55
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunoprecipitation

    • Western Blotting
      View All» Entrez Gene Summary: This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins. View All» UniProt Summary: FUNCTION: SwissProt: Q86WV1 # Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells.SIZE: 359 amino acids; 41462 Da SUBUNIT: Homodimer. Interacts with FYN and PTPRC. Interacts with GRB2 when phosphorylated on Tyr-271. Interacts with FYB, which is required for SKAP2 protein stability. Part of a complex consisting of SKAP1, FYB and CLNK.SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Upon T-cell stimulation, translocates to lipid rafts at the cell membrane.TISSUE SPECIFICITY: Highly expressed in thymocytes and peripheral blood lymphocytes. Also expressed in spleen cells and testis. Present in T-cells (at protein level).DOMAIN:SwissProt: Q86WV1 The SH3 domain interacts with FYB.PTM: Phosphorylated on tyrosines. Phosphorylation by FYN on Tyr- 271 is required for GRB2 interaction. Phosphorylation by FYN on Tyr-295 abolishes interaction with FYB. Tyr-232 is dephosphorylated by PTPRC (Probable).SIMILARITY: Belongs to the SKAP family. & Contains 1 PH domain. & Contains 1 SH3 domain. View All» Brand Family: Upstate View All» Product Name: Anti-SKAP-55 Antibody | 07-651 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
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