金山科研平台，产品价格货期咨询微信：jinshanbio Source:Chinese Hamster Ovary cell line, CHO-derived Accession #:P01215 (TSH alpha ) & P01222 (TSH beta ) N-terminal Sequence Analysis:Ala25 (TSH alpha ) & Phe21 (TSH beta ) Structure:Noncovalently-linked heterodimer Purity:>90%, by SDS-PAGE under reducing conditions and visualized by silver stain. Endotoxin Level: Predicted Molecular Mass:10.2 kDa (TSH alpha ), 13.5 kDa (TSH beta ) SDS-PAGE:15-29 kDa, reducing conditions Activity:Measured by its ability to induce cAMP accumulation in HEK293 human embryonic kidney cells transfected with human TSH R. Morgenthaler, N.G. et al. (1998) Horm. Metab. Res. 30:162.The ED₅₀ for this effect is typically 0.75-3.75 ng/mL. Molecule Information: TSH alpha/beta Long Name: Thyroid Stimulating Hormone Aliases: Thyrotropin Entrez Gene IDs: 7252 (Human) Background: TSH beta/CGa TSH (thyroid stimulating hormone), also known as thyrotropin, is a member of the cystine knot growth factor superfamily. It is a heterodimer of a 15 kDa unique subunit, TSH beta, with a 14 kDa alpha subunit, CGa (common glycoprotein hormone alpha) that is shared with lutropin (LH), follitropin (FSH) and chorionic gonadotropin (CG). Production of TSH by the anterior pituitary gland is stimulated by the hypothalamic peptide TRH, and inhibited by feedback from the thyroid hormones triiodothyronine (T3) and thyroxine (T4). Studies in the mouse identify bone marrow as a secondary site of TSH production.