货号：07-616

品牌：Merck Millipore

规格：

目录价：￥3569.00

市场价格：￥3033.65

会员价格：￥2855.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MEF2A View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: MEF2A View All» Molecular Weight: 66kDa View All» Immunogen: GST fusion protein corresponding to residues 261-315 of human myocyte enhancer factor 2A (MEF2A). View All» Isotype: IgG View All» Species Reactivity: Human View All» Quality Assurance: routinely evaluated by immunoblot from HeLa cells View All» Purification Method: Immunoaffinity purified View All» Presentation: 70% storage buffer (0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide) and 30% glycerol View All» Storage Conditions: 1 year at -20°C View All» UniProt Number: Q02078 View All» Entrez Gene Number: NM_005587 View All» Gene Symbol:

• MEF2A

• MEF2

• RSRFC9

• RSRFC4

• ADCAD1
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The process of differentiation from mesodermal precursor cells to myoblasts has led to the discovery of a variety of tissue-specific factors that regulate muscle gene expression. The myogenic basic helix-loop-helix proteins, including myoD (MIM 159970), myogenin (MIM 159980), MYF5 (MIM 159990), and MRF4 (MIM 159991) are one class of identified factors. A second family of DNA binding regulatory proteins is the myocyte-specific enhancer factor-2 (MEF2) family. Each of these proteins binds to the MEF2 target DNA sequence present in the regulatory regions of many, if not all, muscle-specific genes. The MEF2 genes are members of the MADS gene family (named for the yeast mating type-specific transcription factor MCM1, the plant homeotic genes 'agamous' and 'deficiens' and the human serum response factor SRF (MIM 600589)), a family that also includes several homeotic genes and other transcription factors, all of which share a conserved DNA-binding domain.[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: Q02078 # Transcription factor which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription.SIZE: 507 amino acids; 54811 Da SUBUNIT: Interacts with HDAC7 (By similarity). Heterodimer. Interacts with HDAC4, HDAC9 and SLC2A4RG.SUBCELLULAR LOCATION: Nucleus.TISSUE SPECIFICITY: Isoform MEF2 and isoform MEFA are expressed only in skeletal and cardiac muscle and in the brain while isoform RSRFC4 and isoform RSRFC9 are expressed in all tissues examined.PTM: Constitutively phosphorylated on Ser-408, and dephosphorylated by PPP3CA upon neuron depolarization. Ser-408 phosphorylation promotes Lys-403 sumoylation and inhibits Lys-403 acetylation (By similarity). & Sumoylation on Lys-403 represses transcriptional activity (By similarity). & Acetylation on Lys-403 activates transcriptional activity (By similarity).DISEASE:SwissProt: Q02078 # Defects in MEF2A are a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1) [MIM:608320].SIMILARITY: SwissProt: Q02078 ## Belongs to the MEF2 family. & Contains 1 MADS-box domain. & Contains 1 Mef2-type DNA-binding domain. View All» Brand Family: Upstate View All» Product Name: Anti-MEF2A View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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